Neurodevelopmental and behavioral outcomes of very preterm infants: latent profile analysis in the Environmental influences on Child Health Outcomes (ECHO) Program.
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
25
04
2023
accepted:
29
08
2023
revised:
18
08
2023
pmc-release:
01
07
2024
medline:
22
1
2024
pubmed:
13
9
2023
entrez:
12
9
2023
Statut:
ppublish
Résumé
Very preterm infants are at high risk for neurodevelopmental impairments. We used a child-centered approach (latent profile analysis [LPA]) to describe 2-year neurobehavioral profiles for very preterm infants based on cognitive, motor, and behavioral outcomes. We hypothesized that distinct outcome profiles would differ in the severity and co-occurrence of neurodevelopmental and behavioral impairment. We studied children born <33 weeks' gestation from the Environmental influences on Child Health Outcomes Program with at least one neurobehavioral assessment at age 2 (Bayley Scales of Infant and Toddler Development, Child Behavior Checklist, Modified Checklist for Autism in Toddlers, cerebral palsy diagnosis). We applied LPA to identify subgroups of children with different patterns of outcomes. In 2036 children (52% male; 48% female), we found four distinct neurobehavioral profiles. Most children (~85%) were categorized into one of two profiles characterized by no/mild neurodevelopmental delay and a low prevalence of behavioral problems. Fewer children (~15%) fell into one of two profiles characterized by severe neurodevelopmental impairments. One profile consisted of children (5%) with co-occurring neurodevelopmental impairment and behavioral problems. Child-centered approaches provide a comprehensive, parsimonious description of neurodevelopment following preterm birth and can be useful for clinical and research purposes. Most research on outcomes for children born very preterm have reported rates of impairment in single domains. Child-centered approaches describe profiles of children with unique combinations of cognitive, motor, and behavioral strengths and weaknesses. We capitalized on data from the nationwide Environmental influences on Child Health Outcomes Program to examine these profiles in a large sample of children born <33 weeks gestational age. We found four distinct neurobehavioral profiles consisting of different combinations of cognitive, motor, and behavioral characteristics. This information could aid in the development of clinical interventions that target different profiles of children with unique developmental needs.
Sections du résumé
BACKGROUND
BACKGROUND
Very preterm infants are at high risk for neurodevelopmental impairments. We used a child-centered approach (latent profile analysis [LPA]) to describe 2-year neurobehavioral profiles for very preterm infants based on cognitive, motor, and behavioral outcomes. We hypothesized that distinct outcome profiles would differ in the severity and co-occurrence of neurodevelopmental and behavioral impairment.
METHODS
METHODS
We studied children born <33 weeks' gestation from the Environmental influences on Child Health Outcomes Program with at least one neurobehavioral assessment at age 2 (Bayley Scales of Infant and Toddler Development, Child Behavior Checklist, Modified Checklist for Autism in Toddlers, cerebral palsy diagnosis). We applied LPA to identify subgroups of children with different patterns of outcomes.
RESULTS
RESULTS
In 2036 children (52% male; 48% female), we found four distinct neurobehavioral profiles. Most children (~85%) were categorized into one of two profiles characterized by no/mild neurodevelopmental delay and a low prevalence of behavioral problems. Fewer children (~15%) fell into one of two profiles characterized by severe neurodevelopmental impairments. One profile consisted of children (5%) with co-occurring neurodevelopmental impairment and behavioral problems.
CONCLUSION
CONCLUSIONS
Child-centered approaches provide a comprehensive, parsimonious description of neurodevelopment following preterm birth and can be useful for clinical and research purposes.
IMPACT
CONCLUSIONS
Most research on outcomes for children born very preterm have reported rates of impairment in single domains. Child-centered approaches describe profiles of children with unique combinations of cognitive, motor, and behavioral strengths and weaknesses. We capitalized on data from the nationwide Environmental influences on Child Health Outcomes Program to examine these profiles in a large sample of children born <33 weeks gestational age. We found four distinct neurobehavioral profiles consisting of different combinations of cognitive, motor, and behavioral characteristics. This information could aid in the development of clinical interventions that target different profiles of children with unique developmental needs.
Identifiants
pubmed: 37700161
doi: 10.1038/s41390-023-02814-9
pii: 10.1038/s41390-023-02814-9
pmc: PMC10885008
mid: NIHMS1965429
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
377-385Subventions
Organisme : NIH HHS
ID : U24 OD023382
Pays : United States
Organisme : NIH HHS
ID : U2C OD023375
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH129510
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023348
Pays : United States
Organisme : NIH HHS
ID : U24 OD023319
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023347
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023320
Pays : United States
Organisme : NIH HHS
ID : UG3 OD035513
Pays : United States
Organisme : NIH HHS
ID : UG3 OD035546
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023348
Pays : United States
Investigateurs
P B Smith
(PB)
K L Newby
(KL)
L P Jacobson
(LP)
D J Catellier
(DJ)
R Gershon
(R)
D Cella
(D)
S L Teitelbaum
(SL)
R Vaidya
(R)
R Obeid
(R)
C Rollins
(C)
K Bear
(K)
M Lenski
(M)
R Singh
(R)
M Msall
(M)
Frazier Jo
(F)
A Montgomery
(A)
K Kuban
(K)
L Douglass
(L)
H Jara
(H)
Informations de copyright
© 2023. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
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