Leukemic-phase mucosa-associated lymphoid tissue lymphoma.
IgH rearrangement
Leukemic state
MALT lymphoma
Orbit
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
23
03
2023
accepted:
22
08
2023
revised:
10
08
2023
medline:
27
11
2023
pubmed:
13
9
2023
entrez:
12
9
2023
Statut:
ppublish
Résumé
A 78-year-old man presenting with leukocytosis was admitted to our hospital. The patient was asymptomatic and showed no lymphadenopathy. Peripheral blood flow cytometry revealed a leukemic-phase B-cell lymphoma with medium-to-large abnormal cells with reticulum. Positron emission tomography/computed tomography revealed abnormal uptake in the right orbit, bone marrow, and spleen. We performed immunological staining and fluorescence in situ hybridization on tissues extracted from the right orbit and bone marrow, which led to the diagnosis of mucosa-associated lymphoid tissue (MALT) lymphoma. Polymerase chain reaction analysis of immunoglobulin heavy chain rearrangements in the right orbital mass and bone marrow suggested that they were identical clones. Based on these collective findings, the diagnosis of leukemic-phase MALT lymphoma was confirmed, with sites of involvement including the bone marrow, peripheral blood, right orbit, and spleen. This is a highly rare case of leukemic MALT lymphoma.
Identifiants
pubmed: 37700187
doi: 10.1007/s12185-023-03654-3
pii: 10.1007/s12185-023-03654-3
doi:
Substances chimiques
Immunoglobulin Heavy Chains
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
758-765Informations de copyright
© 2023. Japanese Society of Hematology.
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