Scleredema in the Setting of Monoclonal Gammopathy of Unknown Significance With Progression to Multiple Myeloma: A Case Report.
monoclonal gammopathy of undetermined significance (mgus)
multiple myeloma
organomegaly
plasmacytoma
raynaud’s phenomenon
scleroderma
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
accepted:
09
09
2023
medline:
13
9
2023
pubmed:
13
9
2023
entrez:
13
9
2023
Statut:
epublish
Résumé
Type 2 scleredema on the background of monoclonal gammopathy of undetermined significance (MGUS) is a rare and progressive connective tissue disorder with very few cases reported to date. It is characterized by chronic and diffuse induration of the skin that begins in the upper back and neck and progresses proximally to distally, involving the shoulders, trunk, and arms; the hands are usually spared. Here, we present an unusual case of long-standing scleredema that progressed to involve the hands and fingers. This case was further complicated by new-onset Raynaud's phenomenon, splenomegaly, lymphadenopathy, the development of a plasmacytoma, and eventual progression to multiple myeloma. We highlight the differential diagnoses for his complex presentation, the workup that was completed, and current treatment options.
Identifiants
pubmed: 37701163
doi: 10.7759/cureus.44968
pmc: PMC10492921
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e44968Informations de copyright
Copyright © 2023, Nickell et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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