Microbiome dysbiosis occurred in hypertrophic scars is dominated by
S. aureus
Vancouver Scar Score
hypertrophic scar
inflammation
microbiome dysbiosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
05
2023
accepted:
01
08
2023
medline:
14
9
2023
pubmed:
13
9
2023
entrez:
13
9
2023
Statut:
epublish
Résumé
The mechanisms of hypertrophic scar formation and its tissue inflammation remain unknown. We collected 33 hypertrophic scar (HS) and 36 normal skin (NS) tissues, and detected the tissue inflammation and bacteria using HE staining, Gram staining, and transmission electronic microscopy (TEM), HE staining showed that a dramatically increased number of inflammatory cells accumulated in HS compared with NS, and an enhanced number of bacteria colonies was found in HS by Gram staining, even individual bacteria could be clearly observed by TEM. Microbiome dysbiosis, dominated by
Sections du résumé
Background
The mechanisms of hypertrophic scar formation and its tissue inflammation remain unknown.
Methods
We collected 33 hypertrophic scar (HS) and 36 normal skin (NS) tissues, and detected the tissue inflammation and bacteria using HE staining, Gram staining, and transmission electronic microscopy (TEM),
Results
HE staining showed that a dramatically increased number of inflammatory cells accumulated in HS compared with NS, and an enhanced number of bacteria colonies was found in HS by Gram staining, even individual bacteria could be clearly observed by TEM.
Conclusion
Microbiome dysbiosis, dominated by
Identifiants
pubmed: 37701435
doi: 10.3389/fimmu.2023.1227024
pmc: PMC10494536
doi:
Substances chimiques
Interleukin-6
0
Interleukin-8
0
RNA, Ribosomal, 16S
0
Tumor Necrosis Factor-alpha
0
Gram's stain
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1227024Informations de copyright
Copyright © 2023 Yu, Mao, Zhou, Yuan and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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