The Role of Neuroinflammation in Complex Regional Pain Syndrome: A Comprehensive Review.
complex regional pain syndrome
glial cells
keratinocytes
neurogenic inflammation
neuroinflammation
Journal
Journal of pain research
ISSN: 1178-7090
Titre abrégé: J Pain Res
Pays: New Zealand
ID NLM: 101540514
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
06
2023
accepted:
26
08
2023
medline:
13
9
2023
pubmed:
13
9
2023
entrez:
13
9
2023
Statut:
epublish
Résumé
Complex Regional Pain Syndrome (CRPS) is an excess and/or prolonged pain and inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is multifaceted that remains incompletely understood. Neuroinflammation is an inflammatory response in the peripheral and central nervous systems. Dysregulated neuroinflammation plays a crucial role in the initiation and maintenance of pain and nociceptive neuronal sensitization, which may contribute to the transition from acute to chronic pain and the perpetuation of chronic pain in CRPS. The key features of neuroinflammation encompass infiltration and activation of inflammatory cells and the production of inflammatory mediators in both the central and peripheral nervous systems. This article reviews the role of neuroinflammation in the onset and progression of CRPS from six perspectives: neurogenic inflammation, neuropeptides, glial cells, immune cells, cytokines, and keratinocytes. The objective is to provide insights that can inform future research and development of therapeutic targets for CRPS.
Identifiants
pubmed: 37701560
doi: 10.2147/JPR.S423733
pii: 423733
pmc: PMC10493102
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
3061-3073Subventions
Organisme : NCI NIH HHS
ID : K08 CA228039
Pays : United States
Informations de copyright
© 2023 Wen et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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