Enhanced cell viscosity: A new phenotype associated with lamin A/C alterations.

Biological sciences Biotechnology Cell biology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
20 Oct 2023
Historique:
received: 03 05 2023
revised: 13 07 2023
accepted: 22 08 2023
medline: 13 9 2023
pubmed: 13 9 2023
entrez: 13 9 2023
Statut: epublish

Résumé

Lamin A/C is a well-established key contributor to nuclear stiffness and its role in nucleus mechanical properties has been extensively studied. However, its impact on whole-cell mechanics has been poorly addressed, particularly concerning measurable physical parameters. In this study, we combined microfluidic experiments with theoretical analyses to quantitatively estimate the whole-cell mechanical properties. This allowed us to characterize the mechanical changes induced in cells by lamin A/C alterations and prelamin A accumulation resulting from atazanavir treatment or lipodystrophy-associated LMNA R482W pathogenic variant. Our results reveal a distinctive increase in long-time viscosity as a signature of cells affected by lamin A/C alterations. Furthermore, they show that the whole-cell response to mechanical stress is driven not only by the nucleus but also by the nucleo-cytoskeleton links and the microtubule network. The enhanced cell viscosity assessed with our microfluidic assay could serve as a valuable diagnosis marker for lamin-related diseases.

Identifiants

pubmed: 37701573
doi: 10.1016/j.isci.2023.107714
pii: S2589-0042(23)01791-1
pmc: PMC10494210
doi:

Types de publication

Journal Article

Langues

eng

Pagination

107714

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing financial interests.

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Auteurs

Cécile Jebane (C)

Aix Marseille Univ, CNRS, CINAM, Turing Centre for Living Systems, Marseille, France.

Alice-Anaïs Varlet (AA)

Aix Marseille Univ, INSERM, MMG, Marseille, France.

Marc Karnat (M)

Aix Marseille Univ, Université de Toulon, CNRS, CPT, Turing Centre for Living Systems, Marseille, France.

Lucero M Hernandez-Cedillo (LM)

Aix Marseille Univ, CNRS, CINAM, Turing Centre for Living Systems, Marseille, France.

Amélie Lecchi (A)

Aix Marseille Univ, CNRS, CINAM, Marseille, France.

Frédéric Bedu (F)

Aix Marseille Univ, CNRS, CINAM, Marseille, France.

Camille Desgrouas (C)

Aix Marseille Univ, INSERM, MMG, Marseille, France.

Corinne Vigouroux (C)

Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, National Reference Centre for Rares diseases of Insulin-Secretion and Insulin-Sensitivity (PRISIS), Department of Endocrinology, Paris, France.
Sorbonne University, Saint-Antoine Research Centre, Inserm UMR_S938, Institute of Cardiometabolism and Nutrition, Paris, France.

Marie-Christine Vantyghem (MC)

Endocrinology, Diabetology and Metabolism Department, Inserm U1190, EGID, Lille University Hospital, Lille, France.

Annie Viallat (A)

Aix Marseille Univ, CNRS, CINAM, Turing Centre for Living Systems, Marseille, France.

Jean-François Rupprecht (JF)

Aix Marseille Univ, Université de Toulon, CNRS, CPT, Turing Centre for Living Systems, Marseille, France.

Emmanuèle Helfer (E)

Aix Marseille Univ, CNRS, CINAM, Turing Centre for Living Systems, Marseille, France.

Catherine Badens (C)

Aix Marseille Univ, INSERM, MMG, Marseille, France.
AP-HM, Laboratoire de Biochimie, Marseille, France.

Classifications MeSH