Isochromosome 7p, i(7)(p10): A rare AML, myelodysplasia-related entity.
20q deletion
7q deletion
Acute myeloid leukemia
Chromosome microarray analysis
Mutations
i(7p)
Journal
Leukemia research reports
ISSN: 2213-0489
Titre abrégé: Leuk Res Rep
Pays: England
ID NLM: 101608906
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
07
2023
accepted:
25
08
2023
medline:
13
9
2023
pubmed:
13
9
2023
entrez:
13
9
2023
Statut:
epublish
Résumé
We describe genomic findings in an AML case with isochromosome 7p, i(7)(p10), in which SNP array analysis uncovered an additional 7.07-Mb 20q deletion not detected by karyotyping. Several AML cases with i(7)(p10) as an isolated cytogenetic finding have been previously reported. Based on consequent loss of 7q, we propose that AML with i(7)(p10) represents a distinct entity belonging in the WHO group -7/7q-, which represents one of the genetic abnormalities defining AML, myelodysplasia-related. Additionally, the focal del(20q) identified here adds support for a specific common region of deletion in 20q in myeloid malignancies, implicating a small number of candidate genes.
Identifiants
pubmed: 37701905
doi: 10.1016/j.lrr.2023.100387
pii: S2213-0489(23)00027-4
pmc: PMC10493252
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100387Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors have no financial or personal relationships with other people or organizations that could inappropriately influence the work reported in this manuscript. The research was performed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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