Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex.
Drosophila
Epigenetics
Eye
Imaginal disc
Polycomb
Scalloped
Vestigial
Wing
Journal
Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744
Informations de publication
Date de publication:
15 09 2023
15 09 2023
Historique:
received:
18
04
2023
accepted:
04
09
2023
pmc-release:
25
09
2024
medline:
26
9
2023
pubmed:
13
9
2023
entrez:
13
9
2023
Statut:
ppublish
Résumé
A fundamental goal of developmental biology is to understand how cell and tissue fates are specified. The imaginal discs of Drosophila are excellent model systems for addressing this paradigm as their fate can be redirected when discs regenerate after injury or when key selector genes are misregulated. Here, we show that when Polycomb expression is reduced, the wing selector gene vestigial is ectopically activated. This leads to the inappropriate formation of the Vestigial-Scalloped complex, which forces the eye to transform into a wing. We further demonstrate that disrupting this complex does not simply block wing formation or restore eye development. Instead, immunohistochemistry and high-throughput genomic analysis show that the eye-antennal disc unexpectedly undergoes hyperplastic growth with multiple domains being organized into other imaginal discs and tissues. These findings provide insight into the complex developmental landscape that tissues must navigate before adopting their final fate.
Identifiants
pubmed: 37702007
pii: 329481
doi: 10.1242/dev.201872
pmc: PMC10560572
pii:
doi:
Substances chimiques
Drosophila Proteins
0
Polycomb-Group Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY030847
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
Références
Curr Opin Genet Dev. 2007 Aug;17(4):287-93
pubmed: 17624759
Nat Genet. 2006 Jun;38(6):694-9
pubmed: 16628213
Mol Biol Cell. 2009 Jan;20(1):256-69
pubmed: 18987343
Mech Dev. 1997 Feb;62(1):51-60
pubmed: 9106166
Genetics. 1966 Apr;53(4):785-98
pubmed: 4960022
Cell Rep. 2018 Nov 6;25(6):1561-1576.e7
pubmed: 30404010
Development. 1995 Feb;121(2):589-99
pubmed: 7768195
Annu Rev Cancer Biol. 2020 Mar;4(1):99-119
pubmed: 34164589
PLoS Genet. 2018 Jan 22;14(1):e1007187
pubmed: 29357360
Dev Cell. 2017 Dec 4;43(5):603-617.e5
pubmed: 29207260
Nat Genet. 2009 Oct;41(10):1076-82
pubmed: 19749760
Development. 2018 Apr 4;145(7):
pubmed: 29530880
Cell Rep. 2014 Jun 12;7(5):1456-1470
pubmed: 24857660
Dev Cell. 2003 Nov;5(5):759-71
pubmed: 14602076
Genes Dev. 2015 Jul 15;29(14):1487-92
pubmed: 26178786
Biochem Soc Symp. 1996;62:61-75
pubmed: 8971340
Curr Biol. 1995 Dec 1;5(12):1437-48
pubmed: 8749396
Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5
pubmed: 27079975
Cell. 2017 Feb 9;168(4):613-628
pubmed: 28187284
Dev Biol. 1974 Jan;36(1):212-7
pubmed: 4207180
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Mol Cell. 2020 Feb 20;77(4):840-856.e5
pubmed: 31883952
Nat Genet. 2006 Jun;38(6):700-5
pubmed: 16732288
Development. 2007 Jan;134(2):223-32
pubmed: 17185323
Curr Top Dev Biol. 2010;93:1-28
pubmed: 20959161
Dev Biol. 1976 Feb;48(2):461-5
pubmed: 815114
EMBO J. 1988 May;7(5):1355-63
pubmed: 2842147
Nature. 1978 Dec 7;276(5688):565-70
pubmed: 103000
Development. 2003 Feb;130(3):575-86
pubmed: 12490563
Nature. 1996 Jul 11;382(6587):133-8
pubmed: 8700202
Schizophr Bull. 2001;27(3):457-76
pubmed: 11596847
Genet Res. 1970 Feb;15(1):29-34
pubmed: 5415226
Genetics. 2022 May 5;221(1):
pubmed: 35460415
Epigenetics Chromatin. 2019 Jul 12;12(1):42
pubmed: 31300027
Science. 2002 Nov 1;298(5595):1039-43
pubmed: 12351676
Nature. 1995 May 4;375(6526):58-61
pubmed: 7723843
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Genetics. 1985 Jun;110(2):281-97
pubmed: 3924726
Nature. 2013 Oct 24;502(7472):462-71
pubmed: 24153299
Genetics. 2004 Jan;166(1):187-200
pubmed: 15020417
Development. 2022 Jan 15;149(2):
pubmed: 35088829
Sci Am. 1968 Nov;219(5):110-4 passim
pubmed: 5684924
Genes Dev. 1988 Oct;2(10):1333-43
pubmed: 2849580
Development. 1991 Sep;113(1):273-81
pubmed: 1684933
Genome. 2010 Aug;53(8):575-84
pubmed: 20725144
Genes Dev. 1998 Dec 15;12(24):3900-9
pubmed: 9869643
Development. 1994 Dec;120(12):3473-86
pubmed: 7821215
Cell. 2011 Apr 15;145(2):183-97
pubmed: 21477851
Development. 2021 May 1;148(9):
pubmed: 33982759
Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):
pubmed: 34702735
Development. 2013 Jan 1;140(1):205-15
pubmed: 23222441
Dev Dyn. 2013 Jul;242(7):874-85
pubmed: 23389965
Nat Cell Biol. 2022 Aug;24(8):1192-1201
pubmed: 35941364
Cell. 1983 Dec;35(3 Pt 2):763-76
pubmed: 6418389
Development. 2016 Jul 15;143(14):2494-510
pubmed: 27436039
Epigenetics Chromatin. 2011 Mar 16;4:4
pubmed: 21410956
EMBO J. 1987 Jan;6(1):201-6
pubmed: 16453748
Development. 2005 Jan;132(1):3-13
pubmed: 15590745
Cell. 2002 Oct 18;111(2):197-208
pubmed: 12408864
Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2117-22
pubmed: 10681430
STAR Protoc. 2023 Mar 2;4(1):101878
pubmed: 36867537
Dev Cell. 2021 Aug 9;56(15):2223-2236.e5
pubmed: 34324859
Eur J Cell Biol. 1992 Aug;58(2):429-44
pubmed: 1425777
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
C R Hebd Seances Acad Sci. 1948 Jan 5;226(1):123
pubmed: 18909984
Development. 2001 Sep;128(17):3295-305
pubmed: 11546746
Cell. 2014 Jun 5;157(6):1445-1459
pubmed: 24856970
Elife. 2019 Sep 30;8:
pubmed: 31566561
Gigascience. 2021 Feb 16;10(2):
pubmed: 33590861
Bull Biol Fr Belg. 1948;82(2-3):97-113
pubmed: 18099939
Sci Rep. 2020 Feb 6;10(1):2022
pubmed: 32029803
Nat Genet. 2014 Sep;46(9):973-981
pubmed: 25108384
Nature. 2005 Nov 10;438(7065):234-7
pubmed: 16281037
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15918-23
pubmed: 16247005
Cell. 2002 Oct 18;111(2):185-96
pubmed: 12408863
Dev Biol. 2017 May 1;425(1):58-69
pubmed: 28322734
J Vis Exp. 2014 Sep 20;(91):51792
pubmed: 25285379
Genes Dev. 1998 Dec 15;12(24):3815-20
pubmed: 9869635
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Genetica. 1970;41(1):1-20
pubmed: 4991437
Dev Biol. 2006 Jan 1;289(1):77-90
pubmed: 16307735
Nature. 2012 Aug 16;488(7411):409-13
pubmed: 22801502
Nat Rev Clin Oncol. 2018 Feb;15(2):81-94
pubmed: 29115304
Nucleic Acids Res. 2019 May 7;47(8):e47
pubmed: 30783653
PLoS Genet. 2019 Aug 19;15(8):e1007877
pubmed: 31425502
Trends Genet. 1999 Sep;15(9):371-7
pubmed: 10461206
Dev Cell. 2008 Mar;14(3):388-98
pubmed: 18258486
Nat Genet. 2016 Nov;48(11):1436-1442
pubmed: 27643538
Curr Biol. 2012 Jun 5;22(11):R458-66
pubmed: 22677291
Nature. 2014 Oct 30;514(7524):591-6
pubmed: 25355358
Mol Gen Genet. 1981;183(1):158-62
pubmed: 6799740
J Biosci. 2020;45:
pubmed: 31965990
Front Neurosci. 2020 Apr 28;14:376
pubmed: 32410948
Nature. 2005 Feb 10;433(7026):643-7
pubmed: 15703749
Development. 2020 Aug 26;147(16):
pubmed: 32847824
Genetica. 1968;39(3):329-44
pubmed: 4891802
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Bioessays. 2020 May;42(5):e1900192
pubmed: 32196702
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13439-44
pubmed: 18755899
Development. 2017 Feb 1;144(3):365-373
pubmed: 28143843
Cancer Cell. 2021 Apr 12;39(4):463-465
pubmed: 33848477
Rouxs Arch Dev Biol. 1994 Aug;203(7-8):429-438
pubmed: 28305949
Science. 1995 Mar 24;267(5205):1788-92
pubmed: 7892602
Science. 2003 Nov 14;302(5648):1227-31
pubmed: 14551319
PLoS Genet. 2018 Jan 19;14(1):e1007185
pubmed: 29351292
PLoS One. 2014 Aug 26;9(8):e106211
pubmed: 25157415
EMBO Rep. 2021 Feb 3;22(2):e51644
pubmed: 33480184
Development. 2015 Oct 1;142(19):3274-85
pubmed: 26443632
Development. 2003 Apr;130(8):1537-47
pubmed: 12620980
Genes Dev. 1998 May 15;12(10):1474-82
pubmed: 9585507
Development. 2007 Aug;134(16):3011-20
pubmed: 17634191
Dev Biol. 1998 Feb 15;194(2):196-212
pubmed: 9501029
Genes Dev. 1992 Mar;6(3):367-79
pubmed: 1547938
Nat Genet. 2009 Oct;41(10):1150-5
pubmed: 19749759
Nature. 2010 Jan 28;463(7280):545-8
pubmed: 20072127
Development. 2015 Aug 15;142(16):2740-51
pubmed: 26160905
Cell Death Differ. 2004 Jan;11(1):110-22
pubmed: 14526388
J Cell Biol. 1998 Apr 20;141(2):469-81
pubmed: 9548724
Development. 1996 Nov;122(11):3477-85
pubmed: 8951063
Methods Mol Biol. 2016;1418:335-51
pubmed: 27008022
EMBO J. 1985 Dec 1;4(12):3259-64
pubmed: 2419125
Cell Rep. 2018 Jan 2;22(1):206-217
pubmed: 29298422
Elife. 2015 Feb 26;4:
pubmed: 25719210
Arch Anat Microsc Morphol Exp. 1948;37(1):50-72
pubmed: 18876844
Mech Dev. 1993 Jan;40(1-2):37-46
pubmed: 8095152
Development. 2020 Dec 8;147(23):
pubmed: 33293292
Dev Biol. 2009 Aug 15;332(2):258-72
pubmed: 19500564
EMBO J. 2001 Feb 15;20(4):802-11
pubmed: 11179224
PLoS Genet. 2021 Jul 19;17(7):e1009225
pubmed: 34280185
Genes Dev. 1991 Dec;5(12B):2481-95
pubmed: 1752439
Dev Dyn. 2004 Jan;229(1):162-75
pubmed: 14699588
Development. 2007 Aug;134(16):3001-10
pubmed: 17634192
BMC Bioinformatics. 2011 Jan 26;12:35
pubmed: 21269502
Development. 2003 Mar;130(6):1171-80
pubmed: 12571108
Genetics. 2003 Apr;163(4):1365-73
pubmed: 12702681
Nat Commun. 2021 May 17;12(1):2892
pubmed: 34001903
Nat Struct Mol Biol. 2014 Jun;21(6):569-71
pubmed: 24837194
Cell. 2001 Mar 9;104(5):687-97
pubmed: 11257223
Dev Cell. 2013 May 28;25(4):388-401
pubmed: 23725764
Development. 1999 Oct;126(19):4213-22
pubmed: 10477290
Genes Dev. 1987 Aug;1(6):544-55
pubmed: 3119426
Nucleic Acids Res. 2016 Dec 1;44(21):10132-10149
pubmed: 27557709
FEBS Lett. 2011 Jun 6;585(11):1617-24
pubmed: 21569771