TGF-β Promotes the Postselection Thymic Development and Peripheral Function of IFN-γ-Producing Invariant NKT cells.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
received:
01
11
2022
accepted:
29
08
2023
pmc-release:
01
11
2024
pubmed:
13
9
2023
medline:
13
9
2023
entrez:
13
9
2023
Statut:
ppublish
Résumé
IFN-γ-producing invariant NKT (iNKT)1 cells are lipid-reactive innate-like lymphocytes that are resident in the thymus and peripheral tissues where they protect against pathogenic infection. The thymic functions of iNKT1 cells are not fully elucidated, but subsets of thymic iNKT cells modulate CD8 T cell, dendritic cell, B cell, and thymic epithelial cell numbers or function. In this study, we show that a subset of murine thymic iNKT1 cells required TGF-β-induced signals for their postselection development, to maintain hallmark TGF-β-induced genes, and for expression of the adhesion receptors CD49a and CD103. However, the residency-associated receptor CD69 was not TGF-β signaling-dependent. Recently described CD244+ c2 thymic iNKT1 cells, which produce IFN-γ without exogenous stimulation and have NK-like characteristics, reside in this TGF-β-responsive population. Liver and spleen iNKT1 cells do not share this TGF-β gene signature, but nonetheless TGF-β impacts liver iNKT1 cell phenotype and function. Our findings provide insight into the heterogeneity of mechanisms guiding iNKT1 cell development in different tissues and suggest a close association between a subset of iNKT1 cells and TGF-β-producing cells in the thymus that support their development.
Identifiants
pubmed: 37702745
pii: 265903
doi: 10.4049/jimmunol.2200809
pmc: PMC10592054
mid: NIHMS1929091
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1376-1384Subventions
Organisme : NCI NIH HHS
ID : P30 CA014599
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123396
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007090
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007009
Pays : United States
Informations de copyright
Copyright © 2023 by The American Association of Immunologists, Inc.
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