ISSCR standards for the use of human stem cells in basic research.

The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research to be accurate, meaningful, and durable, standards that ensure reproducibility and reliability of the data should be applied. Although such standards have been previously proposed for repositories and distribution centers, no widely accepted best practices exist for laboratory research with human pluripotent and tissue stem cells. To fill that void, the International Society for Stem Cell Research has developed a set of recommendations, including reporting criteria, for scientists in basic research laboratories. These criteria are designed to be technically and financially feasible and, when implemented, enhance the reproducibility and rigor of stem cell research.

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Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interests This work was supported by the Burroughs Wellcome Fund, the Doris Duke Charitable Foundation, and the Simons Foundation Autism Research Initiative. Additional support to authors provided by the Arto Hardy Family (to J.M.C.); The Novo Nordisk Foundation Center for Stem Cell Medicine, which is supported by the Novo Nordisk Foundation (NNF21CC0073729 to K.B.J. and C.L.M.); the Medical Research Council Professor Award (G1100526/2 to A.G.S.); the Medical Research Council (MR/X000028/1 and MR/X007979/1 to I.B.); the UK Regenerative Medicine Platform (MR/R015724/1 to I.B.); The Francis Crick Institute, which receives its funding from Cancer Research UK (CC0199 to L.E.H.); the UK Medical Research Council (CC0199 to L.E.H.); the Wellcome Trust (CC0199 to L.E.H.); the Medical Research Council (MC_UP_1201/9) and the European Research Council (ERC STG 757710) (M.A.L.); the Korean Fund for Regenerative Medicine (funded by Ministry of Science and ICT) and Ministry of Health and Welfare, Republic of Korea (RS-2022-00070674, to J.S.); and the National Research Foundation of Korea grant funded by the Korean government (MSIT) (no. 2020M3A9E4037903 to J.S.). For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission (L.E.H.). P.A. receives royalty income from the Wistar Institute, Philadelphia, PA, derived from the sale of the TRA series of monoclonal antibodies under license from Wistar, specifically, TRA-1-60, TRA-1-81, TRA-2-49, TRA-2-54, and TRA-1-85 and is a member of the scientific advisory board of TreeFrog Therapeutics. I.B. is a member of the scientific advisory board of WiCell. N.B. is CSO of NewStem Ltd. M.H. is co-inventor of several patents related to organoid technology. M.A.L. is an inventor on several patents related to cerebral organoids, is co-founder and member of the scientific advisory board of a:head bio, and is a member of the scientific advisory board of the Roche Institute for Translational Bioengineering. T.L. is a co-inventor and receives a share of royalties on various hPSC media- and culture-related patents currently owned and licensed by the Wisconsin Alumni Research Foundation (WARF). C.L.M. is an associate editor Stem Cell Reports. M.F.P. is the editor-in-chief of Stem Cell Reports, is a member of the ISSCR board of directors and the International Stem Cell Initiative, and receives compensation for services as editor-in-chief of the journal. J.S. is the founder and CEO of iPS Bio, Inc. Y.S. has the following additional affiliations: Graduate School of Pharmaceutical Sciences, Nagoya City University; Graduate School of Pharmaceutical Sciences, Osaka University; Graduate School of Pharmaceutical Sciences, the University of Tokyo; Faculty of Pharmaceutical Sciences, Tohoku University; and Life Science Technology Project, Kanagawa Institute of Industrial Science and Technology.