The iceberg of genomics: New perspectives in the use of genomics and epigenetics in oncology nursing clinical reasoning. A discursive paper.
DNA
clinical reasoning
epigenetics
genomics
oncology nursing
psychoneuroimmunology
sequence analysis
theoretical nursing
Journal
Journal of advanced nursing
ISSN: 1365-2648
Titre abrégé: J Adv Nurs
Pays: England
ID NLM: 7609811
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
21
08
2023
received:
21
12
2022
accepted:
28
08
2023
medline:
10
11
2023
pubmed:
14
9
2023
entrez:
14
9
2023
Statut:
ppublish
Résumé
Although, there is a wealth of information in the medical literature on the usefulness of genomic testing in assessing risk and its application in medical oncology decision making, there are no theoretical reflections in the nursing field. To understand the implications of molecular biology in nursing practice and highlight the role of Nursing Theory in guiding nurses' reasoning. Searching literature published between 2000 and 2022 in Medline and Google Scholar. Scientific evidence was analysed by the authors expert in different fields. Based on the findings of the literature, concerns have been raised about the proper care of cancer patients who have a genomic risk profile determination. In particular, the absence of theoretical thinking and conceptual models that consider developments in molecular biology and their impact on nursing, in addition to the prevalence of heuristic thinking and the application of clinical patterns in nursing practice, could induce patient misjudgement with inadequate planning of preventive, curative, rehabilitative and educational nursing interventions. Nurses working in the field of oncology should be aware that the risk profile determined by genomics tests is merely the visible and stated portion of the cancer patient: the tip of iceberg. This study demonstrates how genomic testing takes into account a fraction of genes discovered in tumour tissue to establish a risk profile. This subset differs, for example, from the social genome, which can determine the risk of dementia, cancer and cardiovascular disease, but in response to social adversity. Nursing theory, which views the environment as a metaparadigm, must consider a conceptual model that can integrate the findings of genomic testing with recommendations from studies on the social genome of humans to make it easier to build nursing treatments that can better reduce these risks. A nursing theoretical discourse on genomics is a paramount requirement for developing effective nursing care.
Sections du résumé
BACKGROUND
BACKGROUND
Although, there is a wealth of information in the medical literature on the usefulness of genomic testing in assessing risk and its application in medical oncology decision making, there are no theoretical reflections in the nursing field.
AIM
OBJECTIVE
To understand the implications of molecular biology in nursing practice and highlight the role of Nursing Theory in guiding nurses' reasoning.
MATERIALS AND METHODS
METHODS
Searching literature published between 2000 and 2022 in Medline and Google Scholar. Scientific evidence was analysed by the authors expert in different fields.
RESULTS
RESULTS
Based on the findings of the literature, concerns have been raised about the proper care of cancer patients who have a genomic risk profile determination. In particular, the absence of theoretical thinking and conceptual models that consider developments in molecular biology and their impact on nursing, in addition to the prevalence of heuristic thinking and the application of clinical patterns in nursing practice, could induce patient misjudgement with inadequate planning of preventive, curative, rehabilitative and educational nursing interventions. Nurses working in the field of oncology should be aware that the risk profile determined by genomics tests is merely the visible and stated portion of the cancer patient: the tip of iceberg.
DISCUSSION
CONCLUSIONS
This study demonstrates how genomic testing takes into account a fraction of genes discovered in tumour tissue to establish a risk profile. This subset differs, for example, from the social genome, which can determine the risk of dementia, cancer and cardiovascular disease, but in response to social adversity. Nursing theory, which views the environment as a metaparadigm, must consider a conceptual model that can integrate the findings of genomic testing with recommendations from studies on the social genome of humans to make it easier to build nursing treatments that can better reduce these risks.
CONCLUSION
CONCLUSIONS
A nursing theoretical discourse on genomics is a paramount requirement for developing effective nursing care.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4560-4567Informations de copyright
© 2023 The Authors. Journal of Advanced Nursing published by John Wiley & Sons Ltd.
Références
Antoni, M. H., Lutgendorf, S. K., Blomberg, B., Carver, C. S., Lechner, S., Diaz, A., Stagl, J., Arevalo, J. M. G., & Cole, S. W. (2012). Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics. Biological Psychiatry, 71(4), 366-372. https://doi.org/10.1016/j.biopsych.2011.10.007
Beurel, E., Toups, M., & Nemeroff, C. B. (2020). The bidirectional relationship of depression and inflammation: Double trouble. Neuron, 107(2), 234-256. https://doi.org/10.1016/j.neuron.2020.06.002
Bottaccioli, A. G., & Bottaccioli, F. (2020). PsychoNeuroEndocrineImmunology and the science of integrated care. Edra.
Bottaccioli, A. G., Bottaccioli, F., & Minelli, A. (2019). Stress and the psyche-brain-immune network in psychiatric diseases based on psychoneuroendocrineimmunology: A concise review. Annals of the New York Academy of Sciences, 1437(1), 31-42. https://doi.org/10.1111/nyas.13728
Bottaccioli, F. (2010). Filosofia per la medicina, medicina per la filosofia: Grecia e Cina a confronto. Tecniche Nuove.
Bottaccioli, F. (2017). Democrazia della scienza e nella scienza. Una lezione breve ai somari di filosofia e storia della scienza. Pnei News (p. 6).
Cole, S. W. (2014). Human social genomics. PLoS Genetics, 10(8), e1004601. https://doi.org/10.1371/journal.pgen.1004601
Cole, S. W. (2019). The conserved transcriptional response to adversity. Current Opinion in Behavioral Sciences, 28, 31-37. https://doi.org/10.1016/j.cobeha.2019.01.008
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007). Social regulation of gene expression in human leukocytes. Genome Biology, 8(9), R189. https://doi.org/10.1186/gb-2007-8-9-r189
Coulson, J. (2023). Understanding the role of genomics in nursing practice. Nursing Standard, 38(4), 29-34. https://doi.org/10.7748/ns.2022.e12053
Croskerry, P. (2009). Clinical cognition and diagnostic error: Applications of a dual process model of reasoning. Advances in Health Sciences Education, 14(1), 27-35. https://doi.org/10.1007/s10459-009-9182-2
Croskerry, P., Petrie, D. A., Reilly, J. B., & Tait, G. (2014). Deciding about fast and slow decisions. Academic Medicine, 89(2), 197-200. https://doi.org/10.1097/ACM.0000000000000121
de la Cuesta, C. (1983). The nursing process: From development to implementation. Journal of Advanced Nursing, 8(5), 365-371. https://doi.org/10.1111/j.1365-2648.1983.tb00459.x
Dumo, A. M., Laing, B., Lim, A. G., Palaganas, E., Abad, P. J., Valdehueza, O., Palovaara, M., Saunders, H., Estola, M., Mandysova, P., Maguire, J., Ward, L. D., Carlberg, C., & Vehviläinen-Julkunen, K. (2020). Randomized controlled trial on the effectiveness of web-based genomics nursing education intervention for undergraduate nursing students: A study protocol. Journal of Advanced Nursing, 76(11), 3136-3146. https://doi.org/10.1111/jan.14477
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., Miller, A. H., Mantovani, A., Weyand, C. M., Barzilai, N., Goronzy, J. J., Rando, T. A., Effros, R. B., Lucia, A., Kleinstreuer, N., & Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 25(12), 1822-1832. https://doi.org/10.1038/s41591-019-0675-0
Groer, M. W., & McEwen, B. S. (2012). Nursing research in stress, psychoneuroimmunology, and Allostasis. Biological Research for Nursing, 14(4), 309-310. https://doi.org/10.1177/1099800412456731
Hoxhaj, I., Tognetto, A., Acampora, A., Stojanovic, J., & Boccia, S. (2022). Core competencies in cancer genomics for healthcare professionals: Results from a systematic literature review and a Delphi process. Journal of Cancer Education, 37(5), 1332-1342. https://doi.org/10.1007/s13187-021-01956-w
Jairath, N. N., Peden-McAlpine, C. J., Sullivan, M. C., Vessey, J. A., & Henly, S. J. (2018). Theory and theorizing in nursing science: Commentary from the nursing research special issue editorial team. Nursing Research, 67(2), 188-195. https://doi.org/10.1097/NNR.0000000000000273
Kahneman, D., & Tversky, A. (1979). Prospect theory: An analysis of decision under risk. Econometrica, 47(2), 263-291. https://doi.org/10.2307/1914185
Kang, D.-H., Rice, M., Park, N.-J., Turner-Henson, A., & Downs, C. (2010). Stress and inflammation: A biobehavioral approach for nursing research. Western Journal of Nursing Research, 32(6), 730-760. https://doi.org/10.1177/0193945909356556
Koban, L., Gianaros, P. J., Kober, H., & Wager, T. D. (2021). The self in context: Brain systems linking mental and physical health. Nature Reviews Neuroscience, 22(5), 309-322. https://doi.org/10.1038/s41583-021-00446-8
Mahon, S., Calzone, K., Friend, P., Schmitt, M., & Dickman, E. (2022). Filling the void: Genomics resource overview 47th annual oncology nursing society congress, April 27-May 1, 2022, Anaheim, CA. Oncology Nursing Forum, 49(2), 22-23. https://doi.org/10.1188/22.ONF.E1
Marton, G., Pizzoli, S. F. M., Vergani, L., Mazzocco, K., Monzani, D., Bailo, L., Pancani, L., & Pravettoni, G. (2021). Patients' health locus of control and preferences about the role that they want to play in the medical decision-making process. Psychology, Health & Medicine, 26(2), 260-266. https://doi.org/10.1080/13548506.2020.1748211
Mazzocco, K., Milani, A., Ciccarelli, C., Marzorati, C., & Pravettoni, G. (2023). Evidence for choosing qigong as an integrated intervention in cancer care: An umbrella review. Cancers, 15(4), 1176. https://doi.org/10.3390/cancers15041176
McEWEN, B. S. (1998). Stress, adaptation, and disease: Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840(1), 33-44. https://doi.org/10.1111/j.1749-6632.1998.tb09546.x
McEwen, B. S. (2020). The untapped power of allostasis promoted by healthy lifestyles. World Psychiatry, 19(1), 57-58. https://doi.org/10.1002/wps.20720
Meleis, A. I. (2011). Theoretical nursing: Development and progress. Lippincott Williams & Wilkins.
Milani, A., Mauri, S., Gandini, S., & Magon, G. (2013). Oncology nursing minimum data set (ONMDS): Can we hypothesize a set of prevalent nursing sensitive outcomes (NSO) in cancer patients? Ecancermedicalscience, 7, 345. https://doi.org/10.3332/ecancer.2013.345
Moraes, L. J., Miranda, M. B., Loures, L. F., Mainieri, A. G., & Mármora, C. H. C. (2018). A systematic review of psychoneuroimmunology-based interventions. Psychology, Health & Medicine, 23(6), 635-652. https://doi.org/10.1080/13548506.2017.1417607
Mousavinasab, E. S., Rostam Niakan Kalhori, S., Zarifsanaiey, N., Rakhshan, M., & Ghazisaeedi, M. (2020). Nursing process education: A review of methods and characteristics. Nurse Education in Practice, 48, 102886. https://doi.org/10.1016/j.nepr.2020.102886
Rahman, B., McEwen, A., Phillips, J. L., Tucker, K., Goldstein, D., & Jacobs, C. (2022). Genetic and genomic learning needs of oncologists and oncology nurses in the era of precision medicine: A scoping review. Personalized Medicine, 19(2), 139-153. https://doi.org/10.2217/pme-2021-0096
Schluter, J. E. (2023). Understanding the application of genomics knowledge in nursing and midwifery practice: A scoping study. Collegian, 30(2), 306-314. https://doi.org/10.1016/j.colegn.2022.09.011
Sturmberg, J. P. (2021). Health and disease are dynamic complex-adaptive states implications for practice and research. Frontiers in Psychiatry, 12, 595124. https://doi.org/10.3389/fpsyt.2021.595124
Sturmberg, J. P., Picard, M., Aron, D. C., Bennett, J. M., Bircher, J., deHaven, M. J., Gijzel, S. M. W., Heng, H. H., Marcum, J. A., Martin, C. M., Miles, A., Peterson, C. L., Rohleder, N., Walker, C., Olde Rikkert, M. G. M., & Melis, R. J. F. (2019). Health and disease-Emergent states resulting from adaptive social and biological network interactions. Frontiers in Medicine, 6, 59. https://doi.org/10.3389/fmed.2019.00059
Tan, M. W., Lim, F. P., Siew, A. L., Levett-Jones, T., Chua, W. L., & Liaw, S. Y. (2021). Why are physical assessment skills not practiced? A systematic review with implications for nursing education. Nurse Education Today, 99, 104759. https://doi.org/10.1016/j.nedt.2021.104759
Tollefsbol, T. (2021). Medical epigenetics (Vol. 29, 2nd ed.). Academic Press.
Toney-Butler, T. J., & Thayer, J. M. (2023). Nursing process. In StatPearls. StatPearls Publishing http://www.ncbi.nlm.nih.gov/books/NBK499937/
Tsai, M. L., Lillemoe, T. J., Finkelstein, M. J., Money, J. E., Susnik, B., Grimm, E., Kang, S.-H. L., & Swenson, K. K. (2016). Utility of oncotype DX risk assessment in patients with invasive lobular carcinoma. Clinical Breast Cancer, 16(1), 45-50. https://doi.org/10.1016/j.clbc.2015.08.001
van der Wal, J. M., van Borkulo, C. D., Deserno, M. K., Breedvelt, J. J. F., Lees, M., Lokman, J. C., Borsboom, D., Denys, D., van Holst, R. J., Smidt, M. P., Stronks, K., Lucassen, P. J., van Weert, J. C. M., Sloot, P. M. A., Bockting, C. L., & Wiers, R. W. (2021). Advancing urban mental health research: From complexity science to actionable targets for intervention. The Lancet Psychiatry, 8(11), 991-1000. https://doi.org/10.1016/S2215-0366(21)00047-X
Von Ah, D., Brown, C., Brown, S., Bryant, A., Davies, M., Dodd, M., Ferrell, B., Hammer, M., Knobf, M. T., Knoop, T., LoBiondo-Wood, G., Mayer, D., Miaskowski, C., Mitchell, S., Song, L., Watkins Bruner, D., Wesmiller, S., & Cooley, M. (2019). Research agenda of the oncology nursing society: 2019-2022. Oncology Nursing Forum, 46(6), 654-669. https://doi.org/10.1188/19.ONF.654-669
Yao, K., Tong, C.-Y., & Cheng, C. (2022). A framework to predict the applicability of Oncotype DX, MammaPrint, and E2F4 gene signatures for improving breast cancer prognostic prediction. Scientific Reports, 12(1), 2211. https://doi.org/10.1038/s41598-022-06230-7
Yehuda, R., & Lehrner, A. (2018). Intergenerational transmission of trauma effects: Putative role of epigenetic mechanisms. World Psychiatry, 17(3), 243-257. https://doi.org/10.1002/wps.20568
Zhang, T., Wu, X., Peng, G., Zhang, Q., Chen, L., Cai, Z., & Ou, H. (2021). Effectiveness of standardized nursing terminologies for nursing practice and healthcare outcomes: A systematic review. International Journal of Nursing Knowledge, 32(4), 220-228. https://doi.org/10.1111/2047-3095.12315