Identification of galactosamine-(N-acetyl)-6-sulfatase (GALNS) as a novel therapeutic target in progression of nasopharyngeal carcinoma.
AKT
GALNS
Nasopharyngeal carcinoma
Progression
mTOR
Journal
Discover. Oncology
ISSN: 2730-6011
Titre abrégé: Discov Oncol
Pays: United States
ID NLM: 101775142
Informations de publication
Date de publication:
14 Sep 2023
14 Sep 2023
Historique:
received:
04
04
2023
accepted:
24
08
2023
medline:
14
9
2023
pubmed:
14
9
2023
entrez:
14
9
2023
Statut:
epublish
Résumé
Nasopharyngeal carcinoma (NPC) is a commonly diagnosed malignancy in southern China and southeast Asia. Previous studies have identified galactosamine-(N-acetyl)-6-sulfatase (GALNS) as a potential biomarker for multiple cancers. However, it is unknown whether GALNS plays a role in NPC development, and the underlying mechanisms remain unclear. In this study, we found that GALNS is overexpressed in NPC cell lines and tissues compared to the normal nasopharyngeal counterparts. Knocking down GALNS expression in the NPC cells significantly decreased their proliferation in vitro, and inhibited xenograft growth in a mouse model. Mechanistically, the anti-proliferative effect of GALNS silencing was the result of autophagy induction via the inhibition of PI3K-AKT-mTOR signaling pathway. Taken together, GALNS drives the progression of NPC via PI3K-AKT-mTOR signaling-mediated autophagy, and is therefore a promising therapeutic target.
Identifiants
pubmed: 37707658
doi: 10.1007/s12672-023-00782-4
pii: 10.1007/s12672-023-00782-4
pmc: PMC10501037
doi:
Types de publication
Journal Article
Langues
eng
Pagination
171Subventions
Organisme : Shenzhen Key Medical Discipline Construction Fund
ID : SZXK039
Organisme : Basic and Applied Basic Research Foundation of Guangdong Province
ID : 2021A1515010970
Organisme : Shenzhen Innovation of Science and Technology Commission
ID : JCYJ20210324132407019
Informations de copyright
© 2023. Springer Science+Business Media, LLC.
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