Relationship between bone marrow adipose tissue and kidney function in postmenopausal women.
Bone marrow adipose tissue
Bone mineral density
Chronic kidney disease
Estimated glomerular filtration rate
Osteoporosis
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
11
06
2023
revised:
08
08
2023
accepted:
03
09
2023
medline:
15
9
2023
pubmed:
15
9
2023
entrez:
15
9
2023
Statut:
epublish
Résumé
Bone marrow adipose tissue (BMAT) is associated with aging, osteoporosis, and chronic kidney disease (CKD). To date, the association between BMAT and kidney function in postmenopausal women has not been thoroughly investigated. The main purpose of this study was to determine whether a relationship exists between proton density fat fraction (PDFF) and kidney function in postmenopausal women. We investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) - calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation - and PDFF - measured at the lumbar spine and proximal femur using Water Fat Imaging (WFI) MRI - in 199 postmenopausal women from the ADIMOS cohort study. We also performed DXA scans and laboratory measurements of sclerostin and c-terminal Fibroblast Growth Factor 23 (cFGF23). Participants' mean age was 67.5 (standard deviation, SD 10.0) years. Their median eGFR was 85.0 (interquartile range, IQR 72.2-95.0) ml/min/1.73 cm No evidence of an association between kidney function and bone marrow adiposity was found either in the lumbar spine or proximal femur in a cohort of postmenopausal women.
Identifiants
pubmed: 37711545
doi: 10.1016/j.bonr.2023.101713
pii: S2352-1872(23)00061-X
pmc: PMC10498167
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101713Informations de copyright
© 2023 The Authors. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Anne Cotten has received an honorarium from Novartis. Bernard Cortet has received honoraria from Alexion, Amgen, Expanscience, Kyowa-Kirin, MSD, Novartis, Theramex, UCB and Viatris. Julien Paccou has received honoraria from Amgen, MSD, Eli Lilly, Kyowa-Kirin, Theramex and Pfizer. For the remaining authors, none were declared.
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