The impacts of oral and gut microbiota on alveolar bone loss in periodontitis.
alveolar bone resorption
gut-bone axis
lipopolysaccharides
microbiota
periodontitis
short fatty acids
Journal
Journal of periodontal research
ISSN: 1600-0765
Titre abrégé: J Periodontal Res
Pays: United States
ID NLM: 0055107
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
12
06
2023
received:
28
03
2023
accepted:
20
07
2023
medline:
15
11
2023
pubmed:
15
9
2023
entrez:
15
9
2023
Statut:
ppublish
Résumé
Periodontitis, a chronic infectious disease, primarily arises from infections and the invasion of periodontal pathogens. This condition is typified by alveolar bone loss resulting from host immune responses and inflammatory reactions. Periodontal pathogens trigger aberrant inflammatory reactions within periodontal tissues, thereby exacerbating the progression of periodontitis. Simultaneously, these pathogens and metabolites stimulate osteoclast differentiation, which leads to alveolar bone resorption. Moreover, a range of systemic diseases, including diabetes, postmenopausal osteoporosis, obesity and inflammatory bowel disease, can contribute to the development and progression of periodontitis. Many studies have underscored the pivotal role of gut microbiota in bone health through the gut-alveolar bone axis. The circulation may facilitate the transfer of gut pathogens or metabolites to distant alveolar bone, which in turn regulates bone homeostasis. Additionally, gut pathogens can elicit gut immune responses and direct immune cells to remote organs, potentially exacerbating periodontitis. This review summarizes the influence of oral microbiota on the development of periodontitis as well as the association between gut microbiota and periodontitis. By uncovering potential mechanisms of the gut-bone axis, this analysis provides novel insights for the targeted treatment of pathogenic bacteria in periodontitis.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1139-1147Subventions
Organisme : National Natural Science Foundation of China
Organisme : National Nature Science Foundation of China
ID : 81974149
Organisme : National Nature Science Foundation of China
ID : 81991504
Organisme : Innovation Research Team Project of Beijing Stomatological Hospital, Capital Medical University
ID : CXTD202202
Organisme : Innovation Foundation of Beijing Stomatological Hospital, Capital Medical University
ID : 21-09-05
Organisme : Beijing Municipal Administration of Hospitals' Youth Programme
Organisme : Beijing Stomatological Hospital, Capital Medical University Young Scientist Program
ID : YSP202002
Organisme : Beijing Stomatological Hospital, Capital Medical University Young Scientist Program
ID : QML20181501
Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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