Natural mutations of human XDH promote the nitrite (NO

Humans Xanthine Dehydrogenase / genetics Nitrites / metabolism Nitric Oxide / metabolism Oxidoreductases / metabolism Nitrogen Dioxide Hydrogen Peroxide Oxidation-Reduction Uric Acid / metabolism Mutation Xanthine Oxidase / metabolism
Nitrate-nitrite-nitric oxide Nitrite-reductase activity Non-synonymous mutations Superoxide anion Uric acid Xanthine oxidoreductase

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
11 2023
Historique:
received: 06 08 2023
revised: 24 08 2023
accepted: 25 08 2023
medline: 30 10 2023
pubmed: 16 9 2023
entrez: 15 9 2023
Statut: ppublish

Résumé

Several rare genetic variations of human XDH have been shown to alter xanthine oxidoreductase (XOR) activity leading to impaired purine catabolism. However, XOR is a multi-functional enzyme that depending upon the environmental conditions also expresses oxidase activity leading to both O

Identifiants

DOI: 10.1016/j.redox.2023.102864 PMID: 37713777 PMC: PMC10511815
pubmed: 37713777
pii: S2213-2317(23)00265-3
doi: 10.1016/j.redox.2023.102864
pmc: PMC10511815
pii:
doi:

Substances chimiques

Xanthine Dehydrogenase EC 1.17.1.4
Nitrites 0
Nitric Oxide 31C4KY9ESH
Oxidoreductases EC 1.-
Nitrogen Dioxide S7G510RUBH
Hydrogen Peroxide BBX060AN9V
Uric Acid 268B43MJ25
Xanthine Oxidase EC 1.17.3.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102864

Subventions

Organisme : British Heart Foundation
ID : FS/19/62/34901
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Amrita Ahluwalia is a Co-Director of a small start-up Heartbeet Ltd seeking to identify therapeutic opportunities for dietary nitrate.

Auteurs

G Massimo (G)

William Harvey Research Institute, Barts & the London Faculty of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

R S Khambata (RS)

William Harvey Research Institute, Barts & the London Faculty of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

T Chapman (T)

LifeArc, Accelerator Building Open Innovation Campus, Stevenage, SG1 2FX, UK.

K Birchall (K)

LifeArc, Accelerator Building Open Innovation Campus, Stevenage, SG1 2FX, UK.

C Raimondi (C)

William Harvey Research Institute, Barts & the London Faculty of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

A Shabbir (A)

William Harvey Research Institute, Barts & the London Faculty of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

Nicki Dyson (N)

William Harvey Research Institute, Barts & the London Faculty of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

K S Rathod (KS)

William Harvey Research Institute, Barts & the London Faculty of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

C Borghi (C)

Department of Medical and Surgical Sciences, Faculty of Medicine, University of Bologna, Via Massarenti, N.9, 40138, Italy.

A Ahluwalia (A)

Department of Medical and Surgical Sciences, Faculty of Medicine, University of Bologna, Via Massarenti, N.9, 40138, Italy. Electronic address: a.ahluwalia@qmul.ac.uk.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Xanthine dehydrogenase › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Composés chimiques organiques › Nitrites › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Dioxyde d'azote › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Acide urique › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Natural mutations of human XDH promote the nitrite (NO
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Xanthine oxidase › Natural mutations of human XDH promote the nitrite (NO