Electrophysiological Signatures of Visual Recognition Memory across All Layers of Mouse V1.
SRP
long-term habituation
novelty detection
primary visual cortex
stimulus-selective response potentiation
visual recognition memory
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
received:
16
01
2023
revised:
31
08
2023
accepted:
05
09
2023
medline:
3
11
2023
pubmed:
16
9
2023
entrez:
15
9
2023
Statut:
ppublish
Résumé
In mouse primary visual cortex (V1), familiar stimuli evoke significantly altered responses when compared with novel stimuli. This stimulus-selective response plasticity (SRP) was described originally as an increase in the magnitude of visual evoked potentials (VEPs) elicited in layer 4 (L4) by familiar phase-reversing grating stimuli. SRP is dependent on NMDA receptors (NMDARs) and has been hypothesized to reflect potentiation of thalamocortical (TC) synapses in L4. However, recent evidence indicates that the synaptic modifications that manifest as SRP do not occur on L4 principal cells. To shed light on where and how SRP is induced and expressed in male and female mice, the present study had three related aims: (1) to confirm that NMDAR are required specifically in glutamatergic principal neurons of V1, (2) to investigate the consequences of deleting NMDAR specifically in L6, and (3) to use translaminar electrophysiological recordings to characterize SRP expression in different layers of V1. We find that knock-out (KO) of NMDAR in L6 principal neurons disrupts SRP. Current-source density (CSD) analysis of the VEP depth profile shows augmentation of short latency current sinks in layers 3, 4, and 6 in response to phase reversals of familiar stimuli. Multiunit recordings demonstrate that increased peak firing occurs in response to phase reversals of familiar stimuli across all layers, but that activity between phase reversals is suppressed. Together, these data reveal important aspects of the underlying phenomenology of SRP and generate new hypotheses for the expression of experience-dependent plasticity in V1.
Identifiants
pubmed: 37714707
pii: JNEUROSCI.0090-23.2023
doi: 10.1523/JNEUROSCI.0090-23.2023
pmc: PMC10621768
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
7307-7321Subventions
Organisme : NEI NIH HHS
ID : R01 EY023037
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S008276/1
Pays : United Kingdom
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2023 Hayden, Finnie et al.
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