Paraptosis: a non-classical paradigm of cell death for cancer therapy.

ER stress cancer therapy endoplasmic reticulum mitochondria paraptosis

Journal

Acta pharmacologica Sinica
ISSN: 1745-7254
Titre abrégé: Acta Pharmacol Sin
Pays: United States
ID NLM: 100956087

Informations de publication

Date de publication:
15 Sep 2023
Historique:
received: 20 06 2023
accepted: 28 08 2023
medline: 16 9 2023
pubmed: 16 9 2023
entrez: 15 9 2023
Statut: aheadofprint

Résumé

Due to the sustained proliferative potential of cancer cells, inducing cell death is a potential strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic reticulum (ER) and/or mitochondrial swelling and cytoplasmic vacuolization, which is less investigated. Considerable evidence shows that paraptosis can be triggered by various chemical compounds, particularly in cancer cells, thus highlighting the potential application of this non-classical mode of cell death in cancer therapy. Despite these findings, there remain significant gaps in our understanding of the role of paraptosis in cancer. In this review, we summarize the current knowledge on chemical compound-induced paraptosis. The ER and mitochondria are the two major responding organelles in chemical compound-induced paraptosis, which can be triggered by the reduction of protein degradation, disruption of sulfhydryl homeostasis, overload of mitochondrial Ca

Identifiants

pubmed: 37715003
doi: 10.1038/s41401-023-01159-7
pii: 10.1038/s41401-023-01159-7
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society.

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Auteurs

Chun-Cao Xu (CC)

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Yi-Fan Lin (YF)

College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.

Mu-Yang Huang (MY)

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Xiao-Lei Zhang (XL)

National-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510080, China.

Pei Wang (P)

Department of Pharmacology, School of Pharmacy, Naval Medical University/Second Military Medical University, Shanghai, 200433, China.

Ming-Qing Huang (MQ)

College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China. 2010075@fjtcm.edu.cn.

Jin-Jian Lu (JJ)

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. jinjianlu@um.edu.mo.
Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao, China. jinjianlu@um.edu.mo.
MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao, China. jinjianlu@um.edu.mo.
Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, University of Macau, Macao, China. jinjianlu@um.edu.mo.
Zhuhai UM Science & Technology Research Institute, Zhuhai, 519000, China. jinjianlu@um.edu.mo.

Classifications MeSH