NRF2 signalling in cytoprotection and metabolism.
antioxidant
metabolism
mitochondria
supersulfide
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
15 Sep 2023
15 Sep 2023
Historique:
revised:
01
09
2023
received:
06
07
2023
accepted:
09
09
2023
pubmed:
16
9
2023
medline:
16
9
2023
entrez:
16
9
2023
Statut:
aheadofprint
Résumé
The KEAP1-NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1-NRF2 system has been regarded as a sulfur-utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur-mediated redox reactions. NRF2 is a key regulator of cytoprotective genes, such as antioxidant and detoxification genes, and also possesses potent anti-inflammatory activity. Recently NRF2 has been the focus of attention as a regulator of cellular metabolism and mitochondrial function. The NRF2-mediated regulatory mechanisms of metabolites and mitochondria have been considered diverse, but have not yet been fully clarified. This review article provides an overview of molecular mechanisms that regulate NRF2 signalling and its cytoprotective roles, and highlights NRF2 contribution to cellular metabolism, particularly in the context of mitochondrial function and newly-found sulfur metabolism.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Core Research for Evolutionary Science and Technology
ID : JPMJCR2024
Organisme : Japan Agency for Medical Research and Development
ID : JP21zf0127001
Organisme : Japan Society for the Promotion of Science
ID : 22K15504
Organisme : Japan Society for the Promotion of Science
ID : 21H04799
Organisme : Japan Society for the Promotion of Science
ID : 21H05258
Organisme : Japan Society for the Promotion of Science
ID : 21H05263
Organisme : Japan Society for the Promotion of Science
ID : 21H05264
Organisme : Japan Society for the Promotion of Science
ID : 22K19397
Informations de copyright
© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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