Changing the guard-nuclear pore complex quality control.
ESCRT
aging
autophagy
membrane fusion
nuclear envelope
nuclear pore complex
nuclear pore complex assembly
nuclear transport
proteostasis
quality control
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
31
08
2023
received:
19
07
2023
accepted:
31
08
2023
medline:
29
11
2023
pubmed:
16
9
2023
entrez:
16
9
2023
Statut:
ppublish
Résumé
The integrity of the nuclear envelope depends on the function of nuclear pore complexes (NPCs), transport channels that control macromolecular traffic between the nucleus and cytosol. The central importance of NPCs suggests the existence of quality control (QC) mechanisms that oversee their assembly and function. In this perspective, we emphasize the challenges associated with NPC assembly and the need for QC mechanisms that operate at various stages of an NPC's life. This includes cytosolic preassembly QC that helps enforce key nucleoporin-nucleoporin interactions and their ultimate stoichiometry in the NPC in addition to mechanisms that monitor aberrant fusion of the inner and outer nuclear membranes. Furthermore, we discuss whether and how these QC mechanisms may operate to sense faulty mature NPCs to facilitate their repair or removal. The so far uncovered mechanisms for NPC QC provide fertile ground for future research that not only benefits a better understanding of the vital role that NPCs play in cellular physiology but also how loss of NPC function and/or these QC mechanisms might be an input to aging and disease.
Identifiants
pubmed: 37715940
doi: 10.1002/1873-3468.14739
doi:
Substances chimiques
Nuclear Pore Complex Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2739-2749Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM105672
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM105672
Pays : United States
Informations de copyright
© 2023 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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