Total recall: the role of PIDDosome components in neurodegeneration.

Humans Death Domain Receptor Signaling Adaptor Proteins / genetics CRADD Signaling Adaptor Protein / metabolism Caspase 2 / genetics Prospective Studies Apoptosis / physiology
PIDD1 PIDDosome RAIDD caspase-2 cell death neurodegeneration

Journal

Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035

Informations de publication

Date de publication:
12 2023
Historique:
received: 12 07 2023
revised: 23 08 2023
accepted: 25 08 2023
medline: 13 11 2023
pubmed: 17 9 2023
entrez: 16 9 2023
Statut: ppublish

Résumé

The PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell differentiation, tissue homeostasis, and organogenesis and regeneration, caspase-2, RAIDD and PIDD1 engagement in neuronal development was shown. Here, we focus on the involvement of PIDDosome components in neurodegenerative disorders, including retinal neuropathies, different types of brain damage, and Alzheimer's disease (AD), Huntington's disease (HD), and Lewy body disease. We also discuss pathogenic variants of PIDD1, RAIDD, and caspase-2 that are associated with intellectual, behavioral, and psychological abnormalities, together with prospective PIDDosome inhibition strategies and their potential clinical application.

Identifiants

DOI: 10.1016/j.molmed.2023.08.008 PMID: 37716905
pubmed: 37716905
pii: S1471-4914(23)00193-4
doi: 10.1016/j.molmed.2023.08.008
pii:
doi:

Substances chimiques

Death Domain Receptor Signaling Adaptor Proteins 0
CRADD Signaling Adaptor Protein 0
Caspase 2 EC 3.4.22.-

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

996-1013

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Pavel I Volik (PI)

Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia.

Gelina S Kopeina (GS)

Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia.

Boris Zhivotovsky (B)

Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia; Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden. Electronic address: boris.zhivotovsky@ki.se.

Alexey V Zamaraev (AV)

Facuty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia; Engelhardt Institute of Molecular Biology, RAS, 119991 Moscow, Russia. Electronic address: a-zamaraev@yandex.ru.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Total recall: the role of PIDDosome components...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation des récepteurs à domaine de mort › Total recall: the role of PIDDosome components...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation des récepteurs à domaine de mort › Protéine adaptatrice de signalisation CRADD › Total recall: the role of PIDDosome components...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases initiatrices › Caspase-2 › Total recall: the role of PIDDosome components...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Total recall: the role of PIDDosome components...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Total recall: the role of PIDDosome components...