Exosomes secreted by ST3GAL5

ST3G5 exosomes mesothelial cell milky spots peritoneal dissemination

Journal

Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230

Informations de publication

Date de publication:
16 Sep 2023
Historique:
revised: 29 08 2023
received: 26 03 2023
accepted: 15 09 2023
pubmed: 17 9 2023
medline: 17 9 2023
entrez: 16 9 2023
Statut: aheadofprint

Résumé

Peritoneal dissemination of cancer affects patient survival. The behavior of peritoneal mesothelial cells (PMCs) and immune cells influences the establishment of a microenvironment that promotes cancer cell metastasis in the peritoneum. Here, we investigated the roles of lactosylceramide alpha-2,3-sialyltransferase (ST3G5; also known as ST3GAL5 and GM3 synthase) in the exosome-mediated premetastatic niche in peritoneal milky spots (MSs). Exosomes secreted from ST3G5

Identifiants

pubmed: 37716915
doi: 10.1002/1878-0261.13524
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Japan Society for the Promotion of Science
ID : 22H02897
Organisme : Japan Society for the Promotion of Science
ID : 23K18307
Organisme : Takeda Medical Research Foundation

Informations de copyright

© 2023 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

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Auteurs

Misato Horie (M)

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Japan.
Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Japan.

Kurara Takagane (K)

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Japan.

Go Itoh (G)

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Japan.

Sei Kuriyama (S)

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Japan.

Kazuyoshi Yanagihara (K)

Division of Rare Cancer Research, National Cancer Center Research Institute, Tokyo, Japan.

Masakazu Yashiro (M)

Department of Molecular Oncology and Therapeutics, Osaka Metropolitan University Graduate School of Medicine, Japan.

Michinobu Umakoshi (M)

Department of Cellular and Organ Pathology, Akita University Graduate School of Medicine, Japan.

Akiteru Goto (A)

Department of Cellular and Organ Pathology, Akita University Graduate School of Medicine, Japan.

Junichi Arita (J)

Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Japan.

Masamitsu Tanaka (M)

Department of Molecular Medicine and Biochemistry, Akita University Graduate School of Medicine, Japan.

Classifications MeSH