Oral Delivery of Gemcitabine-Loaded Glycocholic Acid-Modified Micelles for Cancer Therapy.
chemotherapy
gemcitabine
glycocholic acid
micelles
oral delivery
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
26 09 2023
26 09 2023
Historique:
pmc-release:
17
09
2024
medline:
27
9
2023
pubmed:
17
9
2023
entrez:
17
9
2023
Statut:
ppublish
Résumé
The clinical utility of gemcitabine, an antimetabolite antineoplastic agent applied in various chemotherapy treatments, is limited due to the required intravenous injection. Although chemical structure modifications of gemcitabine result in enhanced oral bioavailability, these modifications compromise complex synthetic routes and cause unexpected side effects. In this study, gemcitabine-loaded glycocholic acid-modified micelles (Gem-PPG) were prepared for enhanced oral chemotherapy. The
Identifiants
pubmed: 37717223
doi: 10.1021/acsnano.3c04793
pmc: PMC10540784
doi:
Substances chimiques
Gemcitabine
0
Micelles
0
Glycocholic Acid
G59NX3I3RT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18074-18088Références
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