Do cerebrovascular risk factors impact the clinical expression of idiopathic isolated adult-onset dystonia?

Blepharospasm Dystonia Epidemiology Sensory trick Vascular risk factors

Journal

Parkinsonism & related disorders

ISSN: 1873-5126

Titre abrégé: Parkinsonism Relat Disord

Pays: England

ID NLM: 9513583

Informations de publication

Date de publication:
Oct 2023

Historique:

received: 08 05 2023

revised: 06 08 2023

accepted: 06 09 2023

pubmed: 18 9 2023

medline: 18 9 2023

entrez: 17 9 2023

Statut: ppublish

Résumé

Although acquired dystonia may develop following ischaemic/haemorrhagic stroke, the relationship between cerebrovascular disease and idiopathic dystonia has been poorly investigated. This cross sectional study aimed at evaluating the impact of cerebrovascular risk factors on the clinical expression of idiopathic adult onset dystonia (IAOD), with reference to dystonia localization and dystonia-associated features. Data were obtained from the Italian Dystonia Registry. Patients with IAOD were stratified into two groups according to the presence of diabetes mellitus and/or arterial hypertension and/or dyslipidemia and/or heart disease. The two groups were compared for demographic features, dystonia phenotype, and dystonia-associated features (sensory trick, tremor, eye symptoms in blepharospasm, and neck pain in cervical dystonia). A total of 1108 patients participated into the study. Patients who reported one cerebrovascular factor or more (n = 555) had higher age and longer disease duration than patients who did not. On multivariable logistic regression analysis, blepharospasm was the only localization, and sensory trick was the only dystonia-associated feature that was significantly associated with cerebrovascular risk factors. Linear regression analysis showed that the strength of the association between cerebrovascular factors and blepharospasm/sensory trick increased with increasing the number of cerebrovascular factors per patient. Results of the present study showed that cerebrovascular risk factors may be associated with specific features of IAOD that is development of blepharospasm and sensory trick. Further studies are needed to better understand the meaning and the mechanisms underlying this association.

Sections du résumé

BACKGROUND BACKGROUND

METHODS METHODS

Data were obtained from the Italian Dystonia Registry. Patients with IAOD were stratified into two groups according to the presence of diabetes mellitus and/or arterial hypertension and/or dyslipidemia and/or heart disease. The two groups were compared for demographic features, dystonia phenotype, and dystonia-associated features (sensory trick, tremor, eye symptoms in blepharospasm, and neck pain in cervical dystonia).

RESULTS RESULTS

A total of 1108 patients participated into the study. Patients who reported one cerebrovascular factor or more (n = 555) had higher age and longer disease duration than patients who did not. On multivariable logistic regression analysis, blepharospasm was the only localization, and sensory trick was the only dystonia-associated feature that was significantly associated with cerebrovascular risk factors. Linear regression analysis showed that the strength of the association between cerebrovascular factors and blepharospasm/sensory trick increased with increasing the number of cerebrovascular factors per patient.

CONCLUSIONS CONCLUSIONS

Results of the present study showed that cerebrovascular risk factors may be associated with specific features of IAOD that is development of blepharospasm and sensory trick. Further studies are needed to better understand the meaning and the mechanisms underlying this association.

Identifiants

DOI: 10.1016/j.parkreldis.2023.105851 PMID: 37717501

pubmed: 37717501

pii: S1353-8020(23)00930-6

doi: 10.1016/j.parkreldis.2023.105851

pii:

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

105851

Investigateurs

Claudio Zaccone (C)

Denise Cerne (D)

Giovanni Idone (G)

Gina Ferrazzano (G)

Sara Rinaldo (S)

Kais Humaidan (K)

Grazia Devigili (G)

Luigi Polidori (L)

Sonia Mazzucchi (S)

Marina Ramella (M)

Claudia Ledda (C)

Martina Petracca (M)

Valentina Oppo (V)

Elena Contaldi (E)

Marinella Turla (M)

Angelo Fabio Gigante (AF)

Francesca Valentino (F)

Daniela Cassano (D)

Nicola Modugno (N)

Nicola Tambasco (N)

Marco Aguggia (M)

Marcello Romano (M)

Lucio Marinelli (L)

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of competing interest None