Requirements for anti-aquaporin 5 autoantibody production in a mouse model.
aquaporin 5
autoantibody
bacterial ortholog
germinal center
mouse model
self-tolerance
Journal
Molecular oral microbiology
ISSN: 2041-1014
Titre abrégé: Mol Oral Microbiol
Pays: Denmark
ID NLM: 101524770
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
26
07
2023
received:
17
06
2023
accepted:
07
08
2023
pubmed:
18
9
2023
medline:
18
9
2023
entrez:
18
9
2023
Statut:
ppublish
Résumé
Several oral bacteria, including Prevotella melaninogenica (Pm), have aquaporin (AQP) proteins homologous to human AQP5, a major water channel protein targeted in Sjogren's syndrome. This study aimed to understand the antigenic characteristics that induce autoantibodies against an AQP5 "E" epitope (AQP5E) in a mouse model using C57BL/6 mice. Immunization with a PmE-L peptide derived from Pm AQP, which contains amino acid mismatches both at the B- and T-cell epitopes, efficiently induced anti-AQP5E autoantibodies accompanied by increased germinal center (GC) B and follicular helper T cells in the draining lymph nodes. However, PmE, a peptide lacking a T-cell epitope, and AQP5E-L, an AQP5-derived self-peptide, hardly induced either anti-AQP5E autoantibodies or GC responses. Surprisingly, OTII-AQP5E, a peptide that replaced the self T-cell epitope of AQP5E-L with an ovalbumin-derived foreign T-cell epitope, was not any better than AQP5E-L in the induction of anti-AQP5E autoantibodies and GC response, despite the substantial expansion of CD4
Types de publication
Journal Article
Langues
eng
Pagination
442-453Subventions
Organisme : National Research Foundation of Korea (Daejeon, Korea)
ID : 2018R1A5A2024418
Organisme : National Research Foundation of Korea (Daejeon, Korea)
ID : 2020R1A2C2007038
Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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