Assessment of
DAS28
microbiota
periodontitis
rheumatoid arthritis
Journal
Northern clinics of Istanbul
ISSN: 2536-4553
Titre abrégé: North Clin Istanb
Pays: Turkey
ID NLM: 101684520
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
11
2022
revised:
22
12
2022
accepted:
29
01
2023
medline:
18
9
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
epublish
Résumé
To comparatively investigate the periodontal results and microbial load in subgingival biofilm samples (SBS) in rheumatoid arthritis subjects and healthy volunteers. One hundred twenty subjects were classified into different cohorts: healthy (H-C); periodontitis with good systemic health (H-P); rheumatoid arthritis (RA) and good periodontal health (RA-C); and periodontitis with RA (RA-P). The periodontal parameters were recorded, and SBS were collected to determine periodontal pathogens including Epstein-Barr Virus (EBV) and Candida albicans using reverse transcription-polymerase chain reaction (RT-PCR). Subjects that had greater disease course, determined by moderate or high disease activity scores 28 (DAS28), suffered from worse oral health conditions (higher plaque index, gingival index, bleeding on probing, probing depth, and excessive clinical attachment loss) than those with low DAS28 scores. A higher prevalence of Treponema denticola (T. denticola) was observed in the RA-P group. Cyclic citrullinated peptide was associated with the occurrence of T. denticola and Campylobacter rectus. DAS28 using C-reactive protein (DAS28-CRP) had a significant association with Capnocytophaga gingivalis and EBV. The duration of the RA disease was associated with the presence of T. denticola. Subgingival microbial difference could reliably discriminate RA from healthy individuals. Especially, T. denticola and EBV may play a key role in periodontitis associated with RA.
Identifiants
pubmed: 37719252
doi: 10.14744/nci.2023.58998
pii: NCI-10-490
pmc: PMC10500248
doi:
Types de publication
Journal Article
Langues
eng
Pagination
490-500Informations de copyright
© Copyright 2023 by Istanbul Provincial Directorate of Health.
Déclaration de conflit d'intérêts
No conflict of interest was declared by the authors.
Références
J Autoimmun. 2012 Sep;39(3):222-8
pubmed: 22704962
Sci Rep. 2019 Jun 10;9(1):8379
pubmed: 31182740
Front Cell Infect Microbiol. 2022 Jul 18;12:956417
pubmed: 35923803
Periodontol 2000. 2020 Feb;82(1):42-64
pubmed: 31850623
J Clin Med. 2019 Aug 26;8(9):
pubmed: 31454946
Acta Odontol Scand. 1964 Feb;22:121-35
pubmed: 14158464
Anaerobe. 2016 Jun;39:91-6
pubmed: 26996070
Rheumatology (Oxford). 2018 Jul 1;57(7):1162-1172
pubmed: 29562298
Arthritis Rheumatol. 2014 May;66(5):1090-100
pubmed: 24782175
Arthritis Rheum. 1995 Jan;38(1):44-8
pubmed: 7818570
J Transl Med. 2018 Jul 31;16(1):214
pubmed: 30064459
J Periodontal Res. 2017 Aug;52(4):745-754
pubmed: 28321852
J Periodontol. 1967 Nov-Dec;38(6):Suppl:610-6
pubmed: 5237684
Odontology. 2006 Sep;94(1):10-21
pubmed: 16998613
J Periodontol. 2010 Feb;81(2):223-30
pubmed: 20151800
Arch Microbiol. 2013 Jul;195(7):473-82
pubmed: 23689247
Nat Med. 2015 Jul;21(7):808-14
pubmed: 26053625
Joint Bone Spine. 2007 Oct;74(5):418-26
pubmed: 17625943
Acta Odontol Scand. 2022 Mar;80(2):131-139
pubmed: 34379040
Arthritis Res Ther. 2012 Oct 17;14(5):R222
pubmed: 23075462
Arch Oral Biol. 2020 Jun;114:104695
pubmed: 32315811
J Periodontol. 2008 Jun;79(6):979-86
pubmed: 18533773
Nat Genet. 2018 May;50(5):699-707
pubmed: 29662164
Immunol Rev. 2010 Jan;233(1):34-54
pubmed: 20192991
Oral Microbiol Immunol. 1988 Jun;3(2):47-52
pubmed: 3268751
J Rheumatol. 2008 Jan;35(1):70-6
pubmed: 18050377
Inflammation. 2004 Dec;28(6):311-8
pubmed: 16245073
Rheumatology (Oxford). 2013 Jan;52(1):53-61
pubmed: 23192911
Sci Transl Med. 2013 Oct 30;5(209):209ra150
pubmed: 24174326
J Periodontol. 2018 Jun;89 Suppl 1:S173-S182
pubmed: 29926951
J Clin Periodontol. 2003 Sep;30(9):761-72
pubmed: 12956651
J Periodontol. 2017 Apr;88(4):368-379
pubmed: 27858553
J Transl Med. 2015 Aug 29;13:283
pubmed: 26319714
J Periodontol. 2016 Apr;87(4):346-56
pubmed: 26609697
Nat Rev Rheumatol. 2009 Apr;5(4):218-24
pubmed: 19337286
Lancet. 2005 Nov 19;366(9499):1809-20
pubmed: 16298220
FEMS Yeast Res. 2015 Nov;15(7):
pubmed: 26347504
Int J Mol Sci. 2019 Sep 13;20(18):
pubmed: 31540277
Arthritis Res Ther. 2014 Feb 11;16(1):R50
pubmed: 24513269
J Rheumatol. 2013 May;40(5):611-6
pubmed: 23547208
Microorganisms. 2019 Oct 09;7(10):
pubmed: 31600905
Oral Dis. 2019 Nov;25(8):2003-2009
pubmed: 31411781
Microb Pathog. 2011 Oct;51(4):250-4
pubmed: 21742026
J Periodontol. 2018 Jun;89 Suppl 1:S74-S84
pubmed: 29926944
Braz J Microbiol. 2008 Apr;39(2):226-32
pubmed: 24031206
Arthritis Rheum. 2010 Sep;62(9):2569-81
pubmed: 20872595
Front Microbiol. 2017 Sep 27;8:1853
pubmed: 29033912
Adv Dent Res. 1993 Aug;7(2):163-74
pubmed: 8260004
Curr Opin Rheumatol. 2013 Mar;25(2):241-7
pubmed: 23370377
Periodontol 2000. 2014 Feb;64(1):198-210
pubmed: 24320964
Int J Paleopathol. 2016 Dec;15:128-133
pubmed: 29539547
J Periodontol. 2011 Oct;82(10):1424-32
pubmed: 21405936
Ann Rheum Dis. 2021 Feb;80(2):162-168
pubmed: 33004333