Genetic Polymorphism of NQO1 Influences Susceptibility to Coronary Heart Disease in a Chinese Population: A Cross-Sectional Study and Meta-Anaylsis.
NQO1
coronary heart disease
gene polymorphism
meta-analysis
nursing
Journal
Pharmacogenomics and personalized medicine
ISSN: 1178-7066
Titre abrégé: Pharmgenomics Pers Med
Pays: New Zealand
ID NLM: 101514107
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
05
2023
accepted:
11
08
2023
medline:
18
9
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
epublish
Résumé
The present study is to explore the association between NQO1 gene polymorphism and coronary heart disease (CHD) risk. This research were selected 80 CHD patients as the observation group and 130 healthy people who participated in normal physical examination during the same period as the control group. NQO1 gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. In addition, we conducted a meta-analysis to summarize the results of three relevant previously published adult population studies on the association between NQO1 gene polymorphism and coronary heart disease (CHD) risk. There were three genotypes (CC, CT, and TT) for NQO1 C609T polymorphism. The significant associations were found in TT genotype and T allele (all NQO1 gene polymorphism increased the CHD risk in a Chinese population. Combined with individual gene polymorphism, the accuracy of risk assessment for CHD can be improved and individualized health education can be provided for CHD patients by nurses.
Identifiants
pubmed: 37720192
doi: 10.2147/PGPM.S420874
pii: 420874
pmc: PMC10503550
doi:
Types de publication
Journal Article
Langues
eng
Pagination
825-833Informations de copyright
© 2023 Zhou et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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