Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice.

anti-inflammatory dysregulation immune pathology interleukin-36γ liver injury rift valley fever virus type I interferon

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 27 03 2023
accepted: 16 08 2023
medline: 19 9 2023
pubmed: 18 9 2023
entrez: 18 9 2023
Statut: epublish

Résumé

Type I interferons (IFN) are pro-inflammatory cytokines which can also exert anti-inflammatory effects via the regulation of interleukin (IL)-1 family members. Several studies showed that interferon receptor (IFNAR)-deficient mice develop severe liver damage upon treatment with artificial agonists such as acetaminophen or polyinosinic:polycytidylic acid. In order to investigate if these mechanisms also play a role in an acute viral infection, experiments with the

Identifiants

pubmed: 37720217
doi: 10.3389/fimmu.2023.1194733
pmc: PMC10502725
doi:

Substances chimiques

Interleukin-1 0
Receptor, Interferon alpha-beta 156986-95-7
IL1F9 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1194733

Informations de copyright

Copyright © 2023 Anzaghe, Niles, Korotkova, Dominguez, Kronhart, Ortega Iannazzo, Bechmann, Bachmann, Mühl, Kochs and Waibler.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Martina Anzaghe (M)

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

Marc A Niles (MA)

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

Eugenia Korotkova (E)

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

Monica Dominguez (M)

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

Stefanie Kronhart (S)

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

Samira Ortega Iannazzo (S)

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

Ingo Bechmann (I)

Medical Faculty, Institute for Anatomy, University Leipzig, Leipzig, Germany.

Malte Bachmann (M)

Pharmazentrum Frankfurt/ZAFES, University Hospital Frankfurt, Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.

Heiko Mühl (H)

Pharmazentrum Frankfurt/ZAFES, University Hospital Frankfurt, Goethe-University Frankfurt am Main, Frankfurt am Main, Germany.

Georg Kochs (G)

Institute of Virology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Zoe Waibler (Z)

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

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Classifications MeSH