Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo.
Journal
International journal of microbiology
ISSN: 1687-918X
Titre abrégé: Int J Microbiol
Pays: Egypt
ID NLM: 101516125
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
02
2022
revised:
28
10
2022
accepted:
20
08
2023
medline:
18
9
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
epublish
Résumé
Breast cancer is a lethal disease in females worldwide and needs effective treatment. Targeting cancer cells with selective and safe treatment seems like the best choice, as most chemotherapeutic drugs act unselectively. Papaverine showed promising antitumor activity with a high safety profile and increased blood flow through vasodilation. At the same time, it was widely noticed that virotherapy using the Newcastle disease virus proved to be safe and selective against a broad range of cancer cells. Furthermore, combination therapy is favorable, as it attacks cancer cells with multiple mechanisms and enhances virus entrance into the tumor mass, overcoming cancer cells' resistance to therapy. Therefore, we aimed at assessing the novel combination of the AMHA1 strain of Newcastle disease virus (NDV) and nonnarcotic opium alkaloid (papaverine) against breast cancer models in vitro and in vivo.
Identifiants
pubmed: 37720338
doi: 10.1155/2023/3324247
pmc: PMC10504052
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3324247Informations de copyright
Copyright © 2023 Sura Akram et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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