A pancreatic adenocarcinoma mimicking hepatoid carcinoma of uncertain histogenesis: A case report and literature review.
carcinoma
carcinomatosis
hepatoid
pancreatic
peritoneal
Journal
Oncology letters
ISSN: 1792-1082
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
23
09
2022
accepted:
19
06
2023
medline:
18
9
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
epublish
Résumé
In rare cases, metastatic adenocarcinomas of different origin may exhibit the features of hepatoid carcinoma (HC), a rare malignant epithelial tumor, most commonly occurring in the ovaries and stomach, as well as in the pancreas and biliary ducts. A case of a 72-year-old female patient who developed a highly aggressive, poorly differentiated pancreatic ductal adenocarcinoma with peritoneal carcinomatosis, demonstrating hepatoid differentiation upon conventional hematoxylin and eosin staining is reported in the present study. The patient presented with severe abdominal pain, and the radiological investigations performed revealed ovarian and hepatic tumor masses and peritoneal lesions, which were surgically removed. The gross examination of the peritoneum and omentum revealed multiple solid, firm, grey-white nodules, diffusely infiltrating the adipose tissue. The microscopic examination revealed a malignant epithelial proliferation, composed of polygonal cells with abundant eosinophilic cytoplasm and irregular, pleomorphic nuclei. Certain cells presented with intracytoplasmic mucus inclusions, raising suspicion of a HC with an uncertain histogenesis. Immunohistochemical staining was performed, and the tumor cells were found to be positive for cytokeratin (CK)7, CK18 and mucin 5AC, whereas negative staining for CK20, caudal-type homeobox transcription factor 2, α-fetoprotein, paired box gene 8, GATA-binding protein 3 and Wilms tumor 1 were documented. Thus, the diagnosis of metastatic pancreatic adenocarcinoma was established. The main aim of the present study was to provide further knowledge concerning poorly differentiated metastatic adenocarcinoma resembling HC, emphasizing the histopathological and immunohistochemical features of these malignant lesions and raising awareness of the diagnostic difficulties that may arise, as well as the importance of the use immunohistochemistry in differentiating carcinomas of uncertain histogenesis.
Identifiants
pubmed: 37720666
doi: 10.3892/ol.2023.14029
pii: OL-26-4-14029
pmc: PMC10502951
doi:
Types de publication
Case Reports
Langues
eng
Pagination
442Informations de copyright
Copyright: © Iliesiu et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Am J Ther. 2010 Jan-Feb;17(1):79-85
pubmed: 19636248
World J Clin Cases. 2020 Mar 26;8(6):1116-1128
pubmed: 32258082
Cancers (Basel). 2022 Apr 17;14(8):
pubmed: 35454933
Curr Genomics. 2018 Sep;19(6):444-463
pubmed: 30258276
Cancers (Basel). 2021 Jul 08;13(14):
pubmed: 34298645
Rom J Morphol Embryol. 2021 Jul-Sep;62(3):671-678
pubmed: 35263394
World J Gastroenterol. 2005 Nov 7;11(41):6530-4
pubmed: 16425429
Semin Oncol. 2015 Feb;42(1):86-97
pubmed: 25726054
Int J Surg. 2018 May;53:243-256
pubmed: 29337177
Semin Cancer Biol. 2019 Apr;55:70-77
pubmed: 29705685
Head Neck Pathol. 2016 Mar;10(1):68-74
pubmed: 26830399
Int J Mol Sci. 2021 Dec 14;22(24):
pubmed: 34948209
Pharmacogenomics. 2019 Jan;20(2):113-127
pubmed: 30539680
Int J Mol Sci. 2019 Sep 13;20(18):
pubmed: 31540286
Histopathology. 2000 Jul;37(1):55-63
pubmed: 10931219
J Biol Chem. 2013 Jun 28;288(26):18643-59
pubmed: 23667256
Cancer Lett. 2022 Mar 1;528:59-75
pubmed: 34958892
Pathol Res Pract. 2003;199(2):65-70
pubmed: 12747467
J Clin Med. 2021 Nov 22;10(22):
pubmed: 34830745
Hum Pathol. 2012 Mar;43(3):457-61
pubmed: 21992816
World J Gastroenterol. 2021 Apr 7;27(13):1283-1295
pubmed: 33833482
Cancer. 2016 Dec 15;122(24):3765-3775
pubmed: 27649047
Mod Pathol. 2000 Sep;13(9):962-72
pubmed: 11007036
Surg Oncol. 2019 Mar;28:121-127
pubmed: 30851885
Malays J Pathol. 2019 Apr;41(1):59-63
pubmed: 31025640
Cancers (Basel). 2019 Jan 19;11(1):
pubmed: 30669452
Virchows Arch. 2007 Feb;450(2):225-9
pubmed: 17216188
Ther Adv Med Oncol. 2021 Sep 18;13:17588359211045861
pubmed: 34552668
J Clin Oncol. 2020 Aug 5;38(27):3217-3230
pubmed: 32755482
J Gastroenterol Hepatol. 2019 Feb;34(2):330-345
pubmed: 30550622
Hum Pathol. 2000 Sep;31(9):1062-7
pubmed: 11014572
Radiat Oncol. 2019 Aug 8;14(1):141
pubmed: 31395068
Clin Imaging. 2015 Sep-Oct;39(5):750-8
pubmed: 25981735
Expert Rev Anticancer Ther. 2018 Feb;18(2):131-148
pubmed: 29254387
Cell Mol Life Sci. 2022 Jun 14;79(7):362
pubmed: 35699794
Chin Clin Oncol. 2017 Dec;6(6):63
pubmed: 29307203
Drugs. 2020 May;80(7):647-669
pubmed: 32306207
Front Endocrinol (Lausanne). 2020 Sep 30;11:563267
pubmed: 33101198
J Gastrointest Oncol. 2021 Oct;12(5):2461-2474
pubmed: 34790407
JGH Open. 2022 May 07;6(5):292-300
pubmed: 35601131
Ann Diagn Pathol. 1999 Dec;3(6):350-6
pubmed: 10594286
World J Gastroenterol. 2007 Aug 21;13(31):4270-3
pubmed: 17696261
Oncol Res Treat. 2018;41(10):619-625
pubmed: 30286473
ESMO Open. 2022 Dec;7(6):100638
pubmed: 36399952
Am J Med Sci. 2017 Jun;353(6):610-612
pubmed: 28641727
Dig Liver Dis. 2018 Oct;50(10):979-990
pubmed: 30205952
Front Oncol. 2020 Feb 28;10:245
pubmed: 32185128
Clin Cancer Res. 2020 May 15;26(10):2411-2421
pubmed: 31992588
World J Gastrointest Surg. 2019 Mar 27;11(3):143-154
pubmed: 31057699
Expert Opin Ther Targets. 2015 Feb;19(2):213-25
pubmed: 25555392
Hum Pathol. 2002 Nov;33(11):1136-40
pubmed: 12454820
Ann Surg Oncol. 2021 Feb;28(2):1079-1087
pubmed: 32583198
Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188669
pubmed: 34915061
Int J Clin Exp Pathol. 2015 May 01;8(5):5753-60
pubmed: 26191293
Pancreatology. 2020 Sep;20(6):1175-1182
pubmed: 32741713
Am J Surg Pathol. 2003 Oct;27(10):1302-12
pubmed: 14508391
Oncol Lett. 2021 Apr;21(4):246
pubmed: 33664810
Mod Pathol. 2011 Sep;24(9):1237-47
pubmed: 21552209
Surg Case Rep. 2019 Nov 29;5(1):186
pubmed: 31784920
Cancers (Basel). 2020 Jul 20;12(7):
pubmed: 32698500
Case Rep Oncol. 2020 Jul 29;13(2):904-910
pubmed: 32884538
Am J Surg Pathol. 2001 Dec;25(12):1469-77
pubmed: 11717535
Ann Gastroenterol Surg. 2021 Feb 03;5(4):457-466
pubmed: 34337294
Pancreatology. 2012 Sep-Oct;12(5):409-16
pubmed: 23127528
Health Equity. 2021 Mar 22;5(1):143-150
pubmed: 33778318
J Hepatobiliary Pancreat Sci. 2014 Sep;21(9):648-53
pubmed: 24764208
World J Surg Oncol. 2015 May 20;13:185
pubmed: 25986692
Int J Surg Case Rep. 2021 Jun;83:105951
pubmed: 33971555
Bull Cancer. 2011 Dec;98(12):1439-46
pubmed: 22133915
Int J Mol Sci. 2021 May 12;22(10):
pubmed: 34066284
World J Gastrointest Oncol. 2021 Jun 15;13(6):472-494
pubmed: 34163568
Int J Surg Pathol. 2019 Feb;27(1):28-42
pubmed: 29961402
Oncol Res Treat. 2022;45(5):291-298
pubmed: 35130553
Cancers (Basel). 2022 May 24;14(11):
pubmed: 35681557
Gynecol Oncol Rep. 2020 Apr 01;32:100564
pubmed: 32322647
Cancers (Basel). 2019 Jul 16;11(7):
pubmed: 31315222
Cancer Manag Res. 2017 Oct 03;9:471-479
pubmed: 29056856
BMC Cancer. 2021 Jan 9;21(1):43
pubmed: 33422020
Clin Chim Acta. 2019 Jan;488:226-234
pubmed: 30452897
Int Immunopharmacol. 2021 Jun;95:107508
pubmed: 33725635
Surgery. 2012 Oct;152(4):704-11; discussion 711-3
pubmed: 22943841
Ther Adv Med Oncol. 2020 Jun 23;12:1758835920933034
pubmed: 32636941
J Surg Oncol. 2012 Jun 1;105(7):655-61
pubmed: 22213144
Br J Gen Pract. 2013 Feb;63(607):e165-7
pubmed: 23561696
Biochem Med (Zagreb). 2019 Jun 15;29(2):020707
pubmed: 31223261
Hepatobiliary Surg Nutr. 2015 Oct;4(5):354-62
pubmed: 26605284
In Vivo. 2021 Jan-Feb;35(1):31-39
pubmed: 33402447
Int J Gynecol Pathol. 1999 Apr;18(2):125-9
pubmed: 10202669
Int J Surg. 2017 Dec;48:149-154
pubmed: 29081375
Diagn Cytopathol. 2015 Mar;43(3):251-6
pubmed: 24965084
Cancers (Basel). 2022 Sep 22;14(19):
pubmed: 36230515
Updates Surg. 2022 Feb;74(1):43-53
pubmed: 34021484
World J Surg Oncol. 2017 Jan 10;15(1):16
pubmed: 28069033
Med Oncol. 2022 Aug 16;39(11):168
pubmed: 35972607
Int J Gynecol Pathol. 2002 Jan;21(1):4-10
pubmed: 11781516
J Cutan Pathol. 2007 Mar;34(3):226-33
pubmed: 17302606
Cancer Cell Int. 2022 Jun 28;22(1):220
pubmed: 35761336
Sci Rep. 2017 Dec 22;7(1):18056
pubmed: 29273724
Surg Case Rep. 2016 Dec;2(1):78
pubmed: 27488314
Clin Colorectal Cancer. 2014 Dec;13(4):232-8
pubmed: 25442814
Pathol Res Pract. 2012 Mar 15;208(3):163-6
pubmed: 22361037
J Gastrointest Oncol. 2012 Jun;3(2):105-19
pubmed: 22811878
Arch Pathol Lab Med. 2019 Jul;143(7):883-889
pubmed: 30628840
Am J Clin Pathol. 2005 Jan;123(1):66-74
pubmed: 15762281
Pancreatology. 2017 Jan - Feb;17(1):95-102
pubmed: 27746094
Br J Cancer. 2022 Jun;126(12):1676-1683
pubmed: 35197581
Cancers (Basel). 2019 Jun 19;11(6):
pubmed: 31248203
Clin J Gastroenterol. 2019 Dec;12(6):603-608
pubmed: 30993652
Clin Transl Oncol. 2020 Dec;22(12):2170-2174
pubmed: 32447642
World J Gastroenterol. 2013 Jan 21;19(3):321-7
pubmed: 23372352
Lab Invest. 2016 Dec;96(12):1268-1278
pubmed: 27775688
Turk J Biol. 2020 Oct 13;44(5):230-237
pubmed: 33110361
Sci Rep. 2019 Feb 4;9(1):1159
pubmed: 30718559
Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):189-94
pubmed: 10981870
Am J Surg Pathol. 2002 Sep;26(9):1213-21
pubmed: 12218578
Arch Pathol Lab Med. 2002 Dec;126(12):1480-6
pubmed: 12456208
Onco Targets Ther. 2021 Aug 26;14:4575-4578
pubmed: 34471360
Cancer Treat Rev. 2019 Nov;80:101895
pubmed: 31542591
JAMA Oncol. 2020 May 1;6(5):764-771
pubmed: 32053139
PLoS One. 2014 Sep 29;9(9):e107948
pubmed: 25264609
Ann Surg Oncol. 2022 Feb;29(2):1281-1293
pubmed: 34608555
Oncol Res Treat. 2022;45(12):752-763
pubmed: 36310006
Eur J Surg. 1999 Apr;165(4):292-306
pubmed: 10365829
Onco Targets Ther. 2020 Mar 27;13:2551-2562
pubmed: 32273725
Biomedicines. 2022 Dec 09;10(12):
pubmed: 36551952
Hum Pathol. 2004 May;35(5):576-81
pubmed: 15138932
Oncol Rep. 2010 Sep;24(3):767-9
pubmed: 20664985
Int J Mol Sci. 2018 Aug 21;19(9):
pubmed: 30134550
Expert Rev Anticancer Ther. 2018 Jan;18(1):51-62
pubmed: 29125367
Am J Surg Pathol. 2006 Sep;30(9):1130-9
pubmed: 16931958
Cancer Genomics Proteomics. 2017 Jul-Aug;14(4):219-223
pubmed: 28647696
Cancers (Basel). 2018 Sep 13;10(9):
pubmed: 30217058
Curr Treat Options Oncol. 2020 Jun 29;21(8):62
pubmed: 32601814
Oncotarget. 2018 Jan 3;9(11):9789-9807
pubmed: 29515771
Diagnostics (Basel). 2021 Mar 20;11(3):
pubmed: 33804776
Radiographics. 2020 Sep-Oct;40(5):1219-1239
pubmed: 32678699
J Surg Oncol. 2021 May;123(6):1395-1404
pubmed: 33831247
Am J Surg Pathol. 2004 Oct;28(10):1352-9
pubmed: 15371952
Chang Gung Med J. 2012 May-Jun;35(3):285-91
pubmed: 22735061
Eur J Surg Oncol. 2018 Oct;44(10):1486-1493
pubmed: 30146253
BMC Cancer. 2006 Feb 02;6:31
pubmed: 16451736
Cancer Invest. 2001;19(1):65-75
pubmed: 11291558
J Invest Surg. 2023 Dec;36(1):2216756
pubmed: 37455016
PLoS One. 2021 May 20;16(5):e0251656
pubmed: 34015010
J Surg Oncol. 2020 Apr;121(5):881-892
pubmed: 31994193
Oncotarget. 2016 Mar 29;7(13):16505-16
pubmed: 26918727
Geriatrics (Basel). 2018 Nov 26;3(4):
pubmed: 31011120
Am J Surg Pathol. 2021 Jan;45(1):127-136
pubmed: 32991342
Virchows Arch. 2015 Aug;467(2):237-45
pubmed: 25989715
Mol Med Rep. 2015 Oct;12(4):5135-40
pubmed: 26135834
J Cell Mol Med. 2020 Sep;24(18):10560-10572
pubmed: 32779876
Medicine (Baltimore). 2020 May;99(19):e20051
pubmed: 32384467
Am Surg. 2018 Jan 1;84(1):109-113
pubmed: 29428036
Clin Exp Metastasis. 2021 Apr;38(2):187-196
pubmed: 33486670
J Hematol Oncol. 2020 Oct 2;13(1):130
pubmed: 33008426
Ann Gastroenterol Surg. 2022 Oct 11;7(2):326-335
pubmed: 36998299
Ann Surg Oncol. 2021 Mar;28(3):1572-1580
pubmed: 32804325
Ann Surg Oncol. 2020 Jun;27(6):2081-2089
pubmed: 31673938
Am J Pathol. 2019 Jan;189(1):36-43
pubmed: 30558720
Cancer Treat Rev. 2022 Mar;104:102357
pubmed: 35184001
Pancreas. 2020 Nov/Dec;49(10):1264-1275
pubmed: 33122513
Cancer. 2022 Aug 15;128(16):3041-3056
pubmed: 35679197
Abdom Radiol (NY). 2020 Mar;45(3):729-742
pubmed: 31768594
Clin Cancer Res. 2011 Feb 15;17(4):805-16
pubmed: 21325298
Ann Surg Oncol. 2014 Dec;21 Suppl 4:S750-7
pubmed: 25069861
Acta Cytol. 2007 Jan-Feb;51(1):61-5
pubmed: 17328497
Int J Mol Sci. 2020 May 16;21(10):
pubmed: 32429474
World J Gastroenterol. 2015 May 28;21(20):6384-90
pubmed: 26034375
Scand J Gastroenterol. 2006 Sep;41(9):1073-8
pubmed: 16938721
Front Physiol. 2018 Apr 04;9:335
pubmed: 29670543
Dig Surg. 2017;34(2):125-132
pubmed: 27658221
Clin Res Hepatol Gastroenterol. 2021 Mar;45(2):101589
pubmed: 33607375
BMC Cancer. 2017 Apr 7;17(1):249
pubmed: 28388884
Cancers (Basel). 2021 Dec 09;13(24):
pubmed: 34944824