Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis.
astrocytes
demyelination
drug-based therapies
myelin repair
oligodendrocyte precursor cells
reactive astrogliosis
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
medline:
18
9
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
ppublish
Résumé
Astrocytes are indispensable for central nervous system development and homeostasis. In response to injury and disease, astrocytes are integral to the immunological- and the, albeit limited, repair response. In this review, we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal models. We will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate demyelination. Finally, we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.
Identifiants
pubmed: 37721287
pii: NeuralRegenRes_2024_19_3_578_380879
doi: 10.4103/1673-5374.380879
pmc: PMC10581572
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
578-582Déclaration de conflit d'intérêts
None
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