Sleep in 22q11.2 Deletion Syndrome: Current Findings, Challenges, and Future Directions.
22q11.2
Autism
Copy number variation
DiGeorge Syndrome
Psychotic spectrum disorders
Sleep
Sleep spindles
Velocardiofacial Syndrome
Journal
Current psychiatry reports
ISSN: 1535-1645
Titre abrégé: Curr Psychiatry Rep
Pays: United States
ID NLM: 100888960
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
accepted:
28
07
2023
medline:
7
11
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
ppublish
Résumé
To summarize current literature available on sleep in 22q11.2 Deletion Syndrome (22q11.2DS; Velocardiofacial or DiGeorge Syndrome), a neurogenetic disorder caused by a hemizygous deletion in a genomic region critical for neurodevelopment. Due to the greatly increased risk of developmental psychiatric disorders (e.g., autism and schizophrenia) in 22q11.2DS, this review focuses on clinical correlates of sleep disturbances and potential neurobiological underpinnings of these relationships. Sleep disturbances are widely prevalent in 22q11.2DS and are associated with worse behavioral, psychiatric, and physical health outcomes. There are reports of sleep architecture and sleep neurophysiology differences, but the literature is limited by logistical challenges posed by objective sleep measures, resulting in small study samples to date. Sleep disturbances in 22q11.2DS are prevalent and have a substantial impact on well-being. Further investigation of sleep in 22q11.2DS utilizing multimodal sleep assessments has the potential to provide new insight into neurobiological mechanisms and a potential trans-diagnostic treatment target in 22q11.2DS.
Identifiants
pubmed: 37721640
doi: 10.1007/s11920-023-01444-6
pii: 10.1007/s11920-023-01444-6
pmc: PMC10627929
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
479-491Subventions
Organisme : NIMH NIH HHS
ID : U01 MH119736
Pays : United States
Organisme : NIMH NIH HHS
ID : U01MH119736
Pays : United States
Organisme : Autism Speaks
ID : 13530
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH085953
Pays : United States
Organisme : NIH HHS
ID : T32NS048004
Pays : United States
Informations de copyright
© 2023. The Author(s).
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