Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.
Journal
Journal of cardiovascular pharmacology
ISSN: 1533-4023
Titre abrégé: J Cardiovasc Pharmacol
Pays: United States
ID NLM: 7902492
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
06
06
2023
accepted:
28
08
2023
medline:
7
12
2023
pubmed:
18
9
2023
entrez:
18
9
2023
Statut:
epublish
Résumé
Damage to the abdominal aortic wall and the local inflammatory response are key factors resulting in abdominal aortic aneurysm (AAA) formation. During this process, macrophage polarization plays a key role. However, in AAA, the regulatory mechanism of macrophages is still unclear, and further research is needed. In this study, we found that the transcription factor TCF3 was expressed at low levels in AAA. We overexpressed TCF3 and found that TCF3 could inhibit MMP and inflammatory factor expression and promote M2 macrophage polarization, thereby inhibiting the progression of AAA. Knocking down TCF3 could promote M1 polarization and MMP and inflammatory factor expression. In addition, we found that TCF3 increased miR-143-5p expression through transcriptional activation of miR-143-5p , which further inhibited expression of the downstream chemokine CCL20 and promoted M2 macrophage polarization. Our research indicates that TCF3-mediated macrophage polarization plays a key regulatory role in AAA, complementing the role and mechanism of macrophages in the occurrence and development of AAA and providing a scientific basis for AAA treatment.
Identifiants
pubmed: 37721971
doi: 10.1097/FJC.0000000000001484
pii: 00005344-202312000-00006
pmc: PMC10691663
doi:
Substances chimiques
Transcription Factors
0
Chemokine CCL20
0
MicroRNAs
0
TCF3 protein, human
0
Basic Helix-Loop-Helix Transcription Factors
0
CCL20 protein, human
0
MIRN143 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
458-469Subventions
Organisme : Joint Fund of Department of Science and Technology of Yunnan Province- Kunming Medical University
ID : 202301AY070001-100
Organisme : Yunnan Fundamental Research Projects
ID : 202201AT070078
Organisme : Joint Fund of Department of Science and Technology of Yunnan Province- Kunming Medical University
ID : 202201AY070001-241
Organisme : Open Subject of Yunnan Provincial Clinical Medical Center for Geriatric Diseases
ID : 2022 YJZX-LN 12
Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
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