Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus.

Alzheimer’s disease Cross-frequency coupling Gamma Magnetoencephalography (MEG) Subjective memory complaint Theta

Journal

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
ISSN: 1872-8952
Titre abrégé: Clin Neurophysiol
Pays: Netherlands
ID NLM: 100883319

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 13 01 2023
revised: 26 07 2023
accepted: 16 08 2023
pubmed: 19 9 2023
medline: 19 9 2023
entrez: 18 9 2023
Statut: ppublish

Résumé

Subjective cognitive decline (SCD) is associated with increased risks for progressing to Alzheimer's disease (AD). This study aimed to investigate phase-amplitude coupling (PAC) in individuals with SCD and healthy controls (HCs) in the baseline year and determined the predictability of cognitive changes in the clinical follow-up. Resting-state magnetoencephalographic signals in 29 HCs and 23 SCD subjects were recorded in the baseline year. The parahippocampal gyrus, posterior cingulate cortex and precuneus were selected as regions of interest (ROIs). Based on the grand-averaged comodulograms, delta-beta, delta-gamma and theta-gamma PAC values were extracted from each ROI. Compared with the HCs, the SCD group showed decreased theta-gamma PAC in the precuneus. Theta-gamma PAC of the left precuneus was associated with SCD severity and performance of immediate recall in the baseline year. The SCD group was followed for 3 years and divided into SCD-Stable and SCD-Decline groups based on scores of Mini-Mental State Examination. No significant differences in PAC of the baseline year were found between SCD-Stable and SCD-Decline groups. The SCD group demonstrated reduced theta-gamma PAC in the precuneus. Subjective perception of cognitive decline is reflected by objective alterations of brain function.

Identifiants

DOI: 10.1016/j.clinph.2023.08.015 PMID: 37722986
pubmed: 37722986
pii: S1388-2457(23)00713-7
doi: 10.1016/j.clinph.2023.08.015
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

281-289

Informations de copyright

Copyright © 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflict of interest.

Auteurs

Chia-Hsiung Cheng (CH)

Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan. Electronic address: ch.cheng@mail.cgu.edu.tw.

Chun-Che Hung (CC)

Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan.

Yi-Ping Chao (YP)

Department of Computer Science and Information Engineering, Chang Gung University, Taoyuan, Taiwan; Department of Otorhinolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.

Rui Nouchi (R)

Department of Cognitive Health Science, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan.

Pei-Ning Wang (PN)

Division of General Neurology, Department of Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Neurology, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: pnwang@vghtpe.gov.tw.

Classifications MeSH