Microglia moonlighting after traumatic brain injury: aging and interferons influence chronic microglia reactivity.
microglia priming
neurodegeneration
neuroinflammation
neurotrauma
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
12
06
2023
revised:
11
08
2023
accepted:
24
08
2023
pmc-release:
01
11
2024
medline:
23
10
2023
pubmed:
19
9
2023
entrez:
18
9
2023
Statut:
ppublish
Résumé
Most of the individuals who experience traumatic brain injury (TBI) develop neuropsychiatric and cognitive complications that negatively affect recovery and health span. Activation of multiple inflammatory pathways persists after TBI, but it is unclear how inflammation contributes to long-term behavioral and cognitive deficits. One outcome of TBI is microglial priming and subsequent hyper-reactivity to secondary stressors, injuries, or immune challenges that further augment complications. Additionally, microglia priming with aging contributes to exaggerated glial responses to TBI. One prominent inflammatory pathway, interferon (IFN) signaling, is increased after TBI and may contribute to microglial priming and subsequent reactivity. This review discusses the contributions of microglia to inflammatory processes after TBI, as well as the influence of aging and IFNs on microglia reactivity and chronic inflammation after TBI.
Identifiants
pubmed: 37723009
pii: S0166-2236(23)00206-0
doi: 10.1016/j.tins.2023.08.008
pmc: PMC10592045
mid: NIHMS1927683
pii:
doi:
Substances chimiques
Interferons
9008-11-1
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
926-940Subventions
Organisme : NINDS NIH HHS
ID : R01 NS118037
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests in relation to this work.
Références
Neuropathol Appl Neurobiol. 2013 Oct;39(6):654-66
pubmed: 23231074
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
JAMA Neurol. 2017 Oct 1;74(10):1255-1262
pubmed: 28975240
Ann Neurol. 2014 Feb;75(2):241-54
pubmed: 24243523
Brain Behav Immun. 2009 Mar;23(3):309-17
pubmed: 18814846
Biochimie. 2007 Jun-Jul;89(6-7):770-8
pubmed: 17408841
FASEB J. 2005 Aug;19(10):1329-31
pubmed: 15919760
Geroscience. 2022 Jun;44(3):1407-1440
pubmed: 35451674
J Neurosci. 2022 Nov 30;42(48):9082-9096
pubmed: 36257689
Science. 2003 Aug 1;301(5633):640-3
pubmed: 12855817
PLoS One. 2014 May 15;9(5):e97096
pubmed: 24830807
J Neurol. 2020 Oct;267(10):3105-3111
pubmed: 32444981
Front Immunol. 2021 Aug 24;12:710608
pubmed: 34504493
Neuropsychopharmacology. 2008 Sep;33(10):2341-51
pubmed: 18075491
J Neuropathol Exp Neurol. 2011 Jul;70(7):551-67
pubmed: 21666502
Cell. 2020 Mar 5;180(5):833-846.e16
pubmed: 32142677
J Neurosci. 2020 Mar 11;40(11):2357-2370
pubmed: 32029532
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Brain Behav Immun. 2008 Mar;22(3):301-11
pubmed: 17951027
J Neuroinflammation. 2016 Apr 18;13(1):80
pubmed: 27090212
Elife. 2023 Jan 03;12:
pubmed: 36594818
Acta Neuropathol Commun. 2018 Nov 26;6(1):129
pubmed: 30477578
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3516-21
pubmed: 14993594
JAMA Neurol. 2017 Jan 01;74(1):67-74
pubmed: 27893897
Forensic Sci Int. 2004 Dec 16;146(2-3):97-104
pubmed: 15542269
Ann N Y Acad Sci. 2001 Mar;933:222-34
pubmed: 12000023
Sci Adv. 2023 Mar 10;9(10):eadd1101
pubmed: 36888713
Glia. 2018 Dec;66(12):2719-2736
pubmed: 30378170
Nat Rev Immunol. 2021 Sep;21(9):548-569
pubmed: 33833439
J Virol. 2014 May;88(10):5328-41
pubmed: 24600004
Brain Struct Funct. 2012 Jan;217(1):49-61
pubmed: 21597967
PLoS Pathog. 2013;9(5):e1003395
pubmed: 23737750
J Neurotrauma. 2010 Aug;27(8):1529-40
pubmed: 20504161
EBioMedicine. 2018 Feb;28:21-30
pubmed: 29396300
Folia Neuropathol. 2002;40(3):125-31
pubmed: 12572918
Biol Psychiatry. 2014 Oct 1;76(7):575-84
pubmed: 24289885
eNeuro. 2016 Feb 18;3(1):
pubmed: 27022620
Brain Behav Immun. 2022 Nov;106:49-66
pubmed: 35933030
Int J Mol Sci. 2018 May 30;19(6):
pubmed: 29848996
Int J Mol Sci. 2018 Nov 26;19(12):
pubmed: 30486287
Eur J Anaesthesiol Suppl. 2008;42:123-30
pubmed: 18289429
Nat Neurosci. 2020 Feb;23(2):194-208
pubmed: 31959936
Ann Neurol. 2011 Sep;70(3):374-83
pubmed: 21710619
Brain. 2018 Feb 1;141(2):459-471
pubmed: 29272357
Trends Neurosci. 2015 Oct;38(10):609-620
pubmed: 26442695
Front Aging Neurosci. 2017 Jun 28;9:208
pubmed: 28701948
Exp Neurol. 2022 Jul;353:114058
pubmed: 35358498
Immunol Cell Biol. 2012 May;90(5):483-91
pubmed: 22410872
Nat Aging. 2022 Sep;2(9):837-850
pubmed: 37118504
Nat Commun. 2019 Aug 21;10(1):3758
pubmed: 31434879
Neurobiol Aging. 2013 May;34(5):1397-411
pubmed: 23273602
J Neuroinflammation. 2014 Feb 01;11:23
pubmed: 24485070
Mol Cell Neurosci. 2015 May;66(Pt B):75-80
pubmed: 25748121
Biol Psychiatry. 2019 Apr 15;85(8):667-678
pubmed: 30527629
J Neuropsychiatry Clin Neurosci. 2014 Apr 1;26(2):iv-113
pubmed: 24763802
J Neuropsychiatry Clin Neurosci. 2009 Fall;21(4):420-9
pubmed: 19996251
Nat Rev Neurol. 2017 Mar;13(3):171-191
pubmed: 28186177
Mol Neurodegener. 2023 Feb 17;18(1):12
pubmed: 36803190
J Head Trauma Rehabil. 2001 Aug;16(4):343-55
pubmed: 11461657
Brain Behav Immun. 2016 May;54:243-251
pubmed: 26872419
Neurology. 2006 Jan 24;66(2):187-92
pubmed: 16434651
Neuropsychol Rev. 2004 Jun;14(2):87-98
pubmed: 15264710
JAMA Neurol. 2014 Dec;71(12):1490-7
pubmed: 25347255
Brain Behav Immun. 2016 May;54:95-109
pubmed: 26774527
J Neuroinflammation. 2021 Jul 5;18(1):151
pubmed: 34225752
Cell. 2007 Dec 14;131(6):1164-78
pubmed: 18083105
J Neurosci. 2021 Feb 24;41(8):1830-1843
pubmed: 33446516
Front Immunol. 2018 Sep 11;9:2061
pubmed: 30254639
Ann Neurosci. 2018 Dec;25(4):223-233
pubmed: 31000961
Cell. 1990 Jul 27;62(2):379-90
pubmed: 1695551
J Neurosci. 2020 Apr 1;40(14):2960-2974
pubmed: 32094203
J Neuropathol Exp Neurol. 2014 Jan;73(1):14-29
pubmed: 24335533
J Neuroinflammation. 2018 Nov 21;15(1):323
pubmed: 30463579
J Neurochem. 2016 Oct;139 Suppl 2:136-153
pubmed: 26990767
J Neuroinflammation. 2020 Nov 3;17(1):328
pubmed: 33143727
J Neurosci. 2022 May 18;42(20):4215-4228
pubmed: 35440489
Toxins (Basel). 2014 May 26;6(6):1696-723
pubmed: 24866026
J Neuroinflammation. 2020 Jun 17;17(1):193
pubmed: 32552898
Neuropsychologia. 2006;44(10):1995-8
pubmed: 16620889
J Neurosci. 2015 Jan 14;35(2):748-60
pubmed: 25589768
Acta Neuropathol Commun. 2021 Apr 20;9(1):72
pubmed: 33879257
Nat Rev Neurosci. 2013 Feb;14(2):128-42
pubmed: 23329160
Neurotrauma Rep. 2023 Apr 28;4(1):284-296
pubmed: 37139183
J Neuroinflammation. 2012 Oct 30;9:247
pubmed: 23111107
J Neurol Neurosurg Psychiatry. 2012 Nov;83(11):1080-5
pubmed: 22842203
Neural Regen Res. 2018 Oct;13(10):1693-1704
pubmed: 30136679
Front Mol Neurosci. 2022 Feb 25;15:852243
pubmed: 35283725
J Neurosci. 2011 Mar 30;31(13):5089-105
pubmed: 21451046
Neurobiol Dis. 2015 Feb;74:58-65
pubmed: 25447235
J Cereb Blood Flow Metab. 2003 Jun;23(6):748-55
pubmed: 12796723
Front Mol Neurosci. 2021 Feb 23;14:612073
pubmed: 33708071
Brain Inj. 1991 Jul-Sep;5(3):219-32
pubmed: 1933073
Neurobiol Aging. 2019 May;77:194-206
pubmed: 30904769
Neurology. 2018 May 15;90(20):e1771-e1779
pubmed: 29669907
Glia. 2022 May;70(5):913-934
pubmed: 35061297
Am J Psychiatry. 2009 Jun;166(6):653-61
pubmed: 19487401
Arch Phys Med Rehabil. 2008 Dec;89(12 Suppl):S25-34
pubmed: 19081438
Arch Gen Psychiatry. 2004 Jan;61(1):42-50
pubmed: 14706943
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):
pubmed: 33785602
J Neurotrauma. 2000 Aug;17(8):629-40
pubmed: 10972240
Brain. 2013 Jan;136(Pt 1):28-42
pubmed: 23365092
J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):857-62
pubmed: 12810767
Neurobiol Aging. 2017 Apr;52:98-105
pubmed: 28131016
J Neurosurg. 2016 Feb;124(2):511-26
pubmed: 26315003
Neuropsychopharmacology. 2017 Jan;42(1):318-333
pubmed: 27604565
Mol Cell Neurosci. 2015 May;66(Pt B):81-90
pubmed: 25758552
J Neurosci. 2021 Feb 17;41(7):1597-1616
pubmed: 33452227