Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
19 09 2023
19 09 2023
Historique:
received:
23
03
2023
accepted:
29
08
2023
medline:
20
9
2023
pubmed:
19
9
2023
entrez:
18
9
2023
Statut:
epublish
Résumé
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate a calcium-permeable component to fast excitatory neurotransmission. NMDARs are heterotetrameric assemblies of two obligate GluN1 subunits (GRIN1) and two GluN2 subunits (GRIN2A-GRIN2D). Sequencing data shows that 43% (297/679) of all currently known NMDAR disease-associated genetic variants are within the GRIN2A gene, which encodes the GluN2A subunit. Here, we show that unlike missense GRIN2A variants, individuals affected with disease-associated null GRIN2A variants demonstrate a transient period of seizure susceptibility that begins during infancy and diminishes near adolescence. We show increased circuit excitability and CA1 pyramidal cell output in juvenile mice of both Grin2a
Identifiants
pubmed: 37723282
doi: 10.1038/s42003-023-05298-9
pii: 10.1038/s42003-023-05298-9
pmc: PMC10507040
doi:
Substances chimiques
Calcium
SY7Q814VUP
Parvalbumins
0
N-methyl D-aspartate receptor subtype 2A
VH92ICR8HX
Receptors, N-Methyl-D-Aspartate
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
952Subventions
Organisme : NICHD NIH HHS
ID : R01 HD082373
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH127404
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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