The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.
EIF4G
IRES
dTAG
insulin receptor
internal ribosome entry site
translational control
Journal
Molecular and cellular biology
ISSN: 1098-5549
Titre abrégé: Mol Cell Biol
Pays: United States
ID NLM: 8109087
Informations de publication
Date de publication:
2023
2023
Historique:
pmc-release:
19
09
2024
pubmed:
19
9
2023
medline:
19
9
2023
entrez:
19
9
2023
Statut:
ppublish
Résumé
IRES mediated translation initiation requires a different repertoire of factors than canonical cap-dependent translation. Treatments that inhibit the canonical translation factor EIF4G1 have little or no effect on the ability of the Insr and Igf1r cellular IRESes to promote translation. Transcripts for two cellular receptors contain RNA elements that facilitate translation initiation without intact EIF4G1. Cellular IRES mechanisms may resemble viral type III IRESes allowing them to promote translate with a limited number of initiation factors allowing them to work under stress conditions when canonical translation is repressed.
Identifiants
pubmed: 37724583
doi: 10.1080/10985549.2023.2255120
pmc: PMC10569357
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-499Références
Nucleic Acids Res. 2015 Apr 20;43(7):3764-75
pubmed: 25779044
Nat Commun. 2020 Sep 18;11(1):4687
pubmed: 32948771
J Cell Biol. 2008 Apr 21;181(2):293-307
pubmed: 18426977
Cell. 2011 Nov 11;147(4):789-802
pubmed: 22056041
Biochim Biophys Acta. 2009 Sep-Oct;1789(9-10):542-57
pubmed: 19632368
J Biol Chem. 1985 Jun 25;260(12):7651-8
pubmed: 3838990
Biotechnol J. 2015 Apr;10(4):647-53
pubmed: 25650551
J Biol Chem. 2000 Dec 29;275(52):41369-76
pubmed: 11022043
J Biol Chem. 1987 Jan 5;262(1):380-8
pubmed: 3793730
Cell Rep. 2017 Nov 21;21(8):2039-2047
pubmed: 29166596
Cell Mol Life Sci. 2021 Oct;78(19-20):6709-6719
pubmed: 34559254
Virus Res. 2009 Feb;139(2):172-82
pubmed: 18692097
Biochem J. 2012 Nov 15;448(1):1-11
pubmed: 22909319
Annu Rev Biochem. 2019 Jun 20;88:307-335
pubmed: 31220979
J Cell Biol. 2012 Apr 2;197(1):45-57
pubmed: 22472439
EMBO J. 2000 Oct 16;19(20):5533-41
pubmed: 11032820
Nat Commun. 2018 Aug 3;9(1):3068
pubmed: 30076308
EMBO J. 1999 Sep 1;18(17):4865-74
pubmed: 10469664
Bioessays. 1989 Nov;11(5):128-32
pubmed: 2556117
PLoS One. 2008 Feb 13;3(2):e1583
pubmed: 18270573
Genes Dev. 2007 Jan 15;21(2):175-83
pubmed: 17234883
Elife. 2013 Jul 16;2:e00542
pubmed: 23878722
Nat Chem Biol. 2018 May;14(5):431-441
pubmed: 29581585
Cold Spring Harb Perspect Biol. 2019 Apr 1;11(4):
pubmed: 29959190
J Virol. 1994 Sep;68(9):5677-84
pubmed: 8057448
J Biol Chem. 2007 Jan 19;282(3):1695-708
pubmed: 17130132
EMBO J. 2001 Jun 1;20(11):2954-65
pubmed: 11387228
Mol Cell Biol. 2005 Dec;25(23):10556-65
pubmed: 16287867
J Biol Chem. 2013 Nov 15;288(46):32932-40
pubmed: 24092755
FEBS Lett. 1998 Sep 11;435(1):79-83
pubmed: 9755863
J Biol Chem. 2003 Feb 21;278(8):6580-7
pubmed: 12493757
J Biol Chem. 1985 Jul 5;260(13):7843-9
pubmed: 3891747
Nat Biotechnol. 2005 Feb;23(2):222-6
pubmed: 15619617
Cold Spring Harb Perspect Biol. 2013 Feb 01;5(2):
pubmed: 23378589
J Biol Chem. 2006 Aug 11;281(32):22917-32
pubmed: 16766523
Nat Rev Mol Cell Biol. 2005 Apr;6(4):318-27
pubmed: 15803138
Genes Dev. 2002 Nov 15;16(22):2906-22
pubmed: 12435632
Nature. 1988 Jul 28;334(6180):320-5
pubmed: 2839775
J Virol. 1995 Aug;69(8):4950-6
pubmed: 7609064
Science. 2005 Dec 2;310(5753):1513-5
pubmed: 16322461
J Virol. 1994 May;68(5):3183-92
pubmed: 8151781