AtopyReg
Journal
American journal of clinical dermatology
ISSN: 1179-1888
Titre abrégé: Am J Clin Dermatol
Pays: New Zealand
ID NLM: 100895290
Informations de publication
Date de publication:
19 Sep 2023
19 Sep 2023
Historique:
accepted:
28
08
2023
pubmed:
19
9
2023
medline:
19
9
2023
entrez:
19
9
2023
Statut:
aheadofprint
Résumé
AtopyReg Patients were selected based on the following inclusion criteria: age ≥ 18 years; Eczema Area and Severity Index score ≥ 16 or localization in visible or sensitive areas (face, neck, hands, or genitalia), or a Numeric Rating Scale itch score ≥ 7 or a Numeric Rating Scale sleep loss score ≥ 7, or a Dermatology Life Quality Index score ≥ 10. Demographic and clinical data at baseline were recorded and analyzed. A total of 1170 patients (male 51.1%; mean age: 44.7 years; range 18-90 years) were enrolled by 12 Italian Dermatology Units between January 2019 and November 2022. Skin lesions were eczematous in 83.2% of patients, the most involved site were the flexures (53.9%), face (50.9%), and neck (48.0%). Mean Eczema Area and Severity Index score was 22.3, mean Dermatology Life Quality Index value was 17.6, mean Patient Oriented Eczema Measure score was 13.1, and mean Numeric Rating Scale itch and sleep loss scores were 7.6 and 5.9, respectively. Previous systemic therapies were corticosteroids in 77.7% of patients, antihistamines in 50.3% of patients, and cyclosporine A in 42.6% of patients. This baseline data analysis deriving from AtopyReg
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
AtopyReg
METHODS
METHODS
Patients were selected based on the following inclusion criteria: age ≥ 18 years; Eczema Area and Severity Index score ≥ 16 or localization in visible or sensitive areas (face, neck, hands, or genitalia), or a Numeric Rating Scale itch score ≥ 7 or a Numeric Rating Scale sleep loss score ≥ 7, or a Dermatology Life Quality Index score ≥ 10. Demographic and clinical data at baseline were recorded and analyzed.
RESULTS
RESULTS
A total of 1170 patients (male 51.1%; mean age: 44.7 years; range 18-90 years) were enrolled by 12 Italian Dermatology Units between January 2019 and November 2022. Skin lesions were eczematous in 83.2% of patients, the most involved site were the flexures (53.9%), face (50.9%), and neck (48.0%). Mean Eczema Area and Severity Index score was 22.3, mean Dermatology Life Quality Index value was 17.6, mean Patient Oriented Eczema Measure score was 13.1, and mean Numeric Rating Scale itch and sleep loss scores were 7.6 and 5.9, respectively. Previous systemic therapies were corticosteroids in 77.7% of patients, antihistamines in 50.3% of patients, and cyclosporine A in 42.6% of patients.
CONCLUSIONS
CONCLUSIONS
This baseline data analysis deriving from AtopyReg
Identifiants
pubmed: 37725229
doi: 10.1007/s40257-023-00819-y
pii: 10.1007/s40257-023-00819-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Elettra Antonelli
(E)
Flaminia Antonelli
(F)
Grazia L Artelli
(GL)
Francesca Barei
(F)
Andrea Berardinis
(A)
Leonardo Bianchi
(L)
Alessandro Borghi
(A)
Stefano Dastoli
(S)
Francesco Vico
(F)
Biagina G Mennuni
(BG)
Alessandra Michelucci
(A)
Enrico Pascucci
(E)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
Schuler CF 4th, Billi AC, Maverakis E, et al. Novel insights into atopic dermatitis. J Allergy Clin Immunol. 2022;22:S0091-6749(22)01480-4.
Silverberg JI, Barbarot S, Gadkari A, et al. Atopic dermatitis in the pediatric population: a cross-sectional, international epidemiologic study. Ann Allergy Asthma Immunol. 2021;126(4):417–28.
doi: 10.1016/j.anai.2020.12.020
pubmed: 33421555
Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: results from an international survey. Allergy. 2018;73(6):1284–93.
doi: 10.1111/all.13401
pubmed: 29319189
Patruno C, Napolitano M, Argenziano G, et al. Dupilumab therapy of atopic dermatitis of the elderly: a multicentre, real-life study. J Eur Acad Dermatol Venereol. 2021;35(4):958–64.
doi: 10.1111/jdv.17094
pubmed: 33332697
Gutknecht M, Reinert R, Augustin M. Review of health economic analyses in atopic dermatitis: how diverse is the literature? Expert Rev Pharmacoecon Outcomes Res. 2018;19(2):127–45.
doi: 10.1080/14737167.2019.1549491
pubmed: 30590976
Wollenberg A, Kinberger M, Arents B, et al. European guideline (EuroGuiDerm) on atopic eczema: part I: systemic therapy. J Eur Acad Dermatol Venereol. 2022;36(9):1409–31.
doi: 10.1111/jdv.18345
pubmed: 35980214
Makowska K, Nowaczyk J, Blicharz L, et al. Immunopathogenesis of atopic dermatitis: focus on interleukins as disease drivers and therapeutic targets for novel treatments. Int J Mol Sci. 2023;24(1):781.
doi: 10.3390/ijms24010781
pubmed: 36614224
pmcid: 9820829
Costanzo A, Amerio P, Asero R, et al. Long-term management of moderate-to-severe adult atopic dermatitis: a consensus by the Italian Society of Dermatology and Venereology (SIDeMaST), the Association of Italian Territorial and Hospital Allergists and Immunologists (AAIITO), the Italian Association of Hospital Dermatologists (ADOI), the Italian Society of Allergological, Environmental and Occupational Dermatology (SIDAPA), and the Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). Ital J Dermatol Venerol. 2022;157(1):1–12.
pubmed: 35262308
Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh). 1980;Suppl 92:44–7.
doi: 10.2340/00015555924447
Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. The Eczema Area and Severity Index (EASI): assessment of reliability in atopic dermatitis. EASI Evaluator Group. Exp Dermatol. 2001;10(1):11–8.
doi: 10.1034/j.1600-0625.2001.100102.x
pubmed: 11168575
Reich A, Chatzigeorkidis E, Zeidler C, Osada N, Furue M, Takamori K, et al. Tailoring the cut-off values of the Visual Analogue Scale and Numeric Rating Scale in itch assessment. Acta Derm Venereol. 2017;97(6):759–60.
doi: 10.2340/00015555-2642
pubmed: 28224165
Puelles J, Fofana F, Rodriguez D, Silverberg JI, Wollenberg A, Dias Barbosa C, et al. Psychometric validation and responder definition of the sleep disturbance numerical rating scale in moderate-to-severe atopic dermatitis. Br J Dermatol. 2022;186(2):285–94. https://doi.org/10.1111/bjd.20783 .
doi: 10.1111/bjd.20783
pubmed: 34608623
Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI): a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19(3):210–6. https://doi.org/10.1111/j.1365-2230.1994.tb01167.x .
doi: 10.1111/j.1365-2230.1994.tb01167.x
pubmed: 8033378
Schmitt J, Spuls PI, Thomas KS, Simpson E, Furue M, Deckert S, et al. The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials. J Allergy Clin Immunol. 2014;134(4):800–7. https://doi.org/10.1016/j.jaci.2014.07.043 .
doi: 10.1016/j.jaci.2014.07.043
pubmed: 25282560
Futamura M, Leshem YA, Thomas KS, Nankervis H, Williams HC, Simpson EL. A systematic review of Investigator Global Assessment (IGA) in atopic dermatitis (AD) trials: many options, no standards. J Am Acad Dermatol. 2016;74(2):288–94. https://doi.org/10.1016/j.jaad.2015.09.062 .
doi: 10.1016/j.jaad.2015.09.062
pubmed: 26685719
Charman C, Venn A, Ravenscroft J, Williams H. Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods. Br J Dermatol. 2013;169(6):1326–32.
doi: 10.1111/bjd.12590
pubmed: 24024631
pmcid: 3920642
Girolomoni G, de Bruin-Weller M, Aoki V, et al. Nomenclature and clinical phenotypes of atopic dermatitis. Ther Adv Chronic Dis. 2021;12:20406223211002980.
doi: 10.1177/20406223211002979
Silvestre Salvador JF, Romero-Pérez D, Encabo-Durán B. Atopic dermatitis in adults: a diagnostic challenge. J Investig Allergol Clin Immunol. 2017;27(2):78–88. https://doi.org/10.18176/jiaci.0138 .
doi: 10.18176/jiaci.0138
pubmed: 28071589
Tsai YC, Tsai TF. Overlapping features of psoriasis and atopic dermatitis: from genetics to immunopathogenesis to phenotypes. Int J Mol Sci. 2022;23(10):5518.
doi: 10.3390/ijms23105518
pubmed: 35628327
pmcid: 9143118
Fabbrocini G, Stingeni L, Hansel K, et al. AtopyReg
pubmed: 37153942
Bosma AL, Musters AH, Bloem M, et al. Mapping exercise and status update of eight established registries within the TREatment of ATopic eczema Registry Taskforce. J Eur Acad Dermatol Venereol. 2023;37(1):123–36.
doi: 10.1111/jdv.18566
pubmed: 36018221
Birdi G, Larkin M, Chua SL, Knibb RC. Quality of life and mental well-being of adults with atopic dermatitis living in the UK. Clin Exp Allergy. 2023;53(1):113–7.
doi: 10.1111/cea.14237
pubmed: 36176200
Adesanya EI, Matthewman J, Schonmann Y, et al. Factors associated with depression, anxiety and severe mental illness among adults with atopic eczema or psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2023;188(4):460–70.
doi: 10.1093/bjd/ljac132
pubmed: 36745557
Williamson S, Merritt J, De Benedetto A. Atopic dermatitis in the elderly: a review of clinical and pathophysiological hallmarks. Br J Dermatol. 2020;182(1):47–54.
doi: 10.1111/bjd.18652
pubmed: 30895603
Istituto Nazionale di Statistica. Livelli di istruzione e ritorni occupazionali. Rome: ISTAT; 2022.
Heratizadeh A, Haufe E, Stölzl D, et al. Baseline characteristics, disease severity and treatment history of patients with atopic dermatitis included in the German AD Registry TREATgermany. J Eur Acad Dermatol Venereol. 2020;34(6):1263–72.
doi: 10.1111/jdv.16078
pubmed: 31721316
Ofenloch RF, Schuttelaar ML, Svensson Å, et al. Socioeconomic status and the prevalence of skin and atopic diseases in five European countries. Acta Derm Venereol. 2019;99(3):309–14.
doi: 10.2340/00015555-3082
pubmed: 30426137
Adamson AS. The economics burden of atopic dermatitis. Adv Exp Med Biol. 2017;1027:79–92.
doi: 10.1007/978-3-319-64804-0_8
pubmed: 29063433
Bajwa H, Baghchechi M, Mujahid M, Kang Dufour MS, Langan SM, Abuabara K. Mixed evidence on the relationship between socioeconomic position and atopic dermatitis: a systematic review. J Am Acad Dermatol. 2022;86(2):399–405.
doi: 10.1016/j.jaad.2021.09.018
pubmed: 34547359
Wan J, Mitra N, Hooper SR, Hoffstad OJ, Margolis DJ. Association of atopic dermatitis severity with learning disability in children. JAMA Dermatol. 2021;157(6):651–7.
doi: 10.1001/jamadermatol.2021.0008
Schmidt SAJ, Mailhac A, Darvalics B, et al. Association between atopic dermatitis and educational attainment in Denmark. JAMA Dermatol. 2021;157(6):1–9.
doi: 10.1001/jamadermatol.2021.0009
pubmed: 33851963
pmcid: 8223139
Pálsson K, Slagor RM, Flachs EM, Nørreslet LB, Agner T, Ebbehøj NE. Childhood atopic dermatitis is associated with a decreased chance of completing education later in life: a register-based cohort study. J Eur Acad Dermatol Venereol. 2021;35(9):1849–58.
doi: 10.1111/jdv.17346
pubmed: 33988855
Nørreslet LB, Ebbehøj NE, Ellekilde Bonde JP, Thomsen SF, Agner T. The impact of atopic dermatitis on work life: a systematic review. J Eur Acad Dermatol Venereol. 2018;32(1):23–38.
doi: 10.1111/jdv.14523
pubmed: 28833648
Istituto Superiore di Sanità. Comunicato stampa n°39/2022. Rome: ISS; 2022.
Istituto Nazionale di Statistica. Il Consumo di Alcol in Italia. Rome: ISTAT; 2017.
Pesce G, Marcon A, Carosso A, et al. Adult eczema in Italy: prevalence and associations with environmental factors. J Eur Acad Dermatol Venereol. 2015;29(6):1180–7.
doi: 10.1111/jdv.12784
pubmed: 25363318
Silverberg JI. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123(2):144–51.
doi: 10.1016/j.anai.2019.04.020
pubmed: 31034875
Vakharia PP, Silverberg JI. Adult-onset atopic dermatitis: characteristics and management. Am J Clin Dermatol. 2019;20(6):771–9.
doi: 10.1007/s40257-019-00453-7
pubmed: 31140066
Bieber T, D’Erme AM, Akdis CA, et al. Clinical phenotypes and endophenotypes of atopic dermatitis: where are we, and where should we go? J Allergy Clin Immunol. 2017;139(4):S58-64.
doi: 10.1016/j.jaci.2017.01.008
pubmed: 28390478
Silverberg NB. Typical and atypical clinical appearance of atopic dermatitis. Clin Dermatol. 2017;35(4):354–9.
doi: 10.1016/j.clindermatol.2017.03.007
pubmed: 28709565
Patruno C, Potestio L, Napolitano M. Clinical phenotypes of adult atopic dermatitis and related therapies. Curr Opin Allergy Clin Immunol. 2022;22(4):242–9.
doi: 10.1097/ACI.0000000000000837
pubmed: 35786802
Silverberg JI, Margolis DJ, Boguniewicz M, et al. Distribution of atopic dermatitis lesions in United States adults. J Eur Acad Dermatol Venereol. 2019;33(7):1341–8.
doi: 10.1111/jdv.15574
pubmed: 30883885
Yoo J, Koo HYR, Han K, Lee YB. Impairment of quality of life and mental health status in adult-onset atopic dermatitis. Ann Dermatol. 2022;34(4):278–86.
doi: 10.5021/ad.21.282
pubmed: 35948330
pmcid: 9365647
Drucker AM, Eyerich K, de Bruin-Weller MS, et al. Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement. Br J Dermatol. 2018;178(3):768–75.
doi: 10.1111/bjd.15928
pubmed: 28865094
pmcid: 5901393
He A, Feldman SR, Fleischer AB. An assessment of the use of antihistamines in the management of atopic dermatitis. J Am Acad Dermatol. 2018;79(1):92–6.
doi: 10.1016/j.jaad.2017.12.077
pubmed: 29317281