Predictions from a mathematical approach to model ionic signaling for rapid responses of Sertoli cells exhibit similarities to pharmacological approaches.
Na+/K+ pump
ionic channels
mathematical analysis
rapid responses
sertoli cell
Journal
Biomedical physics & engineering express
ISSN: 2057-1976
Titre abrégé: Biomed Phys Eng Express
Pays: England
ID NLM: 101675002
Informations de publication
Date de publication:
02 10 2023
02 10 2023
Historique:
received:
05
06
2023
accepted:
19
09
2023
medline:
4
10
2023
pubmed:
20
9
2023
entrez:
19
9
2023
Statut:
epublish
Résumé
Sertoli cells are essential for the male reproduction system as they provide morphological support and nutrients for germ cells to guarantee ongoing spermatogenesis. The aim of this work was to predict the electrical properties at the plasma membrane that trigger Sertoli cell rapid responses by involving ionic channels. The rapid responses of Sertoli cells in culture were monitored using patch clamp electrical measurement and compared to data obtained using pharmacological tools (from intact seminiferous tubules). A mathematical model was used to define the roles of potassium channels and the ATP-dependent Na
Identifiants
pubmed: 37725948
doi: 10.1088/2057-1976/acfb07
doi:
Substances chimiques
Potassium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023 IOP Publishing Ltd.