Gene of the month: GATA3.

Humans Female Breast / metabolism Urinary Bladder Neoplasms / genetics Mutation GATA3 Transcription Factor / genetics Breast Neoplasms Biomarkers, Tumor / genetics
breast neoplasms immunohistochemistry molecular biology pathology, molecular urologic neoplasms

Journal

Journal of clinical pathology
ISSN: 1472-4146
Titre abrégé: J Clin Pathol
Pays: England
ID NLM: 0376601

Informations de publication

Date de publication:
Dec 2023
Historique:
accepted: 03 08 2023
medline: 20 11 2023
pubmed: 20 9 2023
entrez: 19 9 2023
Statut: ppublish

Résumé

GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations in

Identifiants

DOI: 10.1136/jcp-2023-209017 PMID: 37726118
pubmed: 37726118
pii: jcp-2023-209017
doi: 10.1136/jcp-2023-209017
doi:

Substances chimiques

GATA3 Transcription Factor 0
Biomarkers, Tumor 0
GATA3 protein, human 0

Types de publication

Review Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

793-797

Informations de copyright

© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Zekai Qiang (Z)

Academic Urology Unit, The University of Sheffield, Sheffield, UK.
ORCID: 0000-0001-8271-8507

Ibrahim Jubber (I)

Academic Urology Unit, The University of Sheffield, Sheffield, UK.

Kirsty Lloyd (K)

Department of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Marcus Cumberbatch (M)

Academic Urology Unit, The University of Sheffield, Sheffield, UK.

Jon Griffin (J)

Academic Urology Unit, The University of Sheffield, Sheffield, UK Jonathan.griffin@sheffield.ac.uk.
Department of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
ORCID: 0000-0003-3969-7637

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gene of the month: GATA3.
questionsmedicales.fr › Régions du corps › Région mammaire › Gene of the month: GATA3.
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de la vessie urinaire › Gene of the month: GATA3.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Gene of the month: GATA3.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription GATA › Facteur de transcription GATA-3 › Gene of the month: GATA3.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Gene of the month: GATA3.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Gene of the month: GATA3.