Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM.
Alzheimer’s disease
Amyloid precursor protein
Lateral diffusion
Nanodomains
Nanoscale organization
PICALM
Risk factors
Single particle tracking
Super resolution microscopy
Synapses
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
20 Sep 2023
20 Sep 2023
Historique:
received:
05
04
2023
accepted:
25
07
2023
revised:
10
07
2023
medline:
21
9
2023
pubmed:
20
9
2023
entrez:
19
9
2023
Statut:
epublish
Résumé
Recently, the localization of amyloid precursor protein (APP) into reversible nanoscale supramolecular assembly or "nanodomains" has been highlighted as crucial towards understanding the onset of the molecular pathology of Alzheimer's disease (AD). Surface expression of APP is regulated by proteins interacting with it, controlling its retention and lateral trafficking on the synaptic membrane. Here, we evaluated the involvement of a key risk factor for AD, PICALM, as a critical regulator of nanoscale dynamics of APP. Although it was enriched in the postsynaptic density, PICALM was also localized to the presynaptic active zone and the endocytic zone. PICALM colocalized with APP and formed nanodomains with distinct morphological properties in different subsynaptic regions. Next, we evaluated if this localization to subsynaptic compartments was regulated by the C-terminal sequences of APP, namely, the "Y
Identifiants
pubmed: 37726569
doi: 10.1007/s00018-023-04939-w
pii: 10.1007/s00018-023-04939-w
doi:
Substances chimiques
Amyloid beta-Protein Precursor
0
PICALM protein, human
0
Monomeric Clathrin Assembly Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
295Subventions
Organisme : SERB INDIA
ID : CORE RESEARCH GRANT
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : GENOMICS ENGINEERING TASKFORCE
Organisme : CBR-FABRIC
ID : CBR-FABRIC/22/01
Organisme : Indian Institute of Science
ID : REDA
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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