Relationship between cardiac mechanical properties and cardiac magnetic resonance imaging at rest in childhood acute lymphoblastic leukemia survivors.
CMR parameters
Cancer research
CircAdapt model
Doxorubicin-related cardiotoxicity
Late adverse effects
Survivorship
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
30
08
2022
accepted:
05
09
2023
medline:
4
12
2023
pubmed:
20
9
2023
entrez:
20
9
2023
Statut:
ppublish
Résumé
The characterization of cardiac mechanical properties may contribute to better understanding of doxorubicin-induced cardiotoxicity. Our study aims to investigate the relationship between cardiac mechanical properties, T1 and T2 relaxation times and partition coefficient. Fifty childhood acute lymphoblastic leukemia survivors underwent a cardiac magnetic resonance (CMR) at rest on a 3T MRI system and included a standard ECG-gated 3(3)3(3)5 MOLLI sequence for T1 mapping and an ECG-gated T2-prepared TrueFISP sequence for T2 mapping. Partition coefficient, ejection fraction, end-diastolic volume (EDV) and end-systolic volume (ESV) were calculated. CircAdapt model was used to study cardiac mechanical performance (left ventricle stiffness (LVS), contractility (LVC) and pressure (Pmin and Pmax), cardiac work efficiency (CWE) and ventricular arterial coupling). In the whole cohort, our results showed that LVC (R
Identifiants
pubmed: 37728802
doi: 10.1007/s10554-023-02953-4
pii: 10.1007/s10554-023-02953-4
doi:
Substances chimiques
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2589-2598Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
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