A CCL2
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 09 2023
20 09 2023
Historique:
received:
01
01
2023
accepted:
04
09
2023
medline:
22
9
2023
pubmed:
21
9
2023
entrez:
20
9
2023
Statut:
epublish
Résumé
Creeping fat is a typical feature of Crohn's disease. It refers to the expansion of mesenteric adipose tissue around inflamed and fibrotic intestines and is associated with stricture formation and intestinal obstruction. In this study, we characterize creeping fat as pro-adipogenic and pro-fibrotic. Lipidomics analysis of Crohn's disease patients (sixteen males, six females) and healthy controls (five males, ten females) reveals abnormal lipid metabolism in creeping fat. Through scRNA-seq analysis on mesenteric adipose tissue from patients (five males, one female) and healthy controls (two females), we identify a CCL2
Identifiants
pubmed: 37730641
doi: 10.1038/s41467-023-41418-z
pii: 10.1038/s41467-023-41418-z
pmc: PMC10511504
doi:
Substances chimiques
Dipeptidyl Peptidase 4
EC 3.4.14.5
Interleukin-6
0
CCL2 protein, human
0
Chemokine CCL2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5830Informations de copyright
© 2023. Springer Nature Limited.
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