Prominent and conspicuous astrocyte atrophy in human sporadic and familial Alzheimer's disease.
Alzheimer’s disease
Astrocytes
Atrophy
Entorhinal Cortex
Familial Alzheimer’s
GFAP
GS
Sporadic Alzheimer’s
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
26
06
2023
accepted:
31
08
2023
medline:
6
11
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
Pathophysiology of sporadic Alzheimer's disease (SAD) and familial Alzheimer's disease (FAD) remains poorly known, including the exact role of neuroglia and specifically astroglia, in part because studies of astrocytes in human Alzheimer's disease (AD) brain samples are scarce. As far as we know, this is the first study of a 3-D immunohistochemical and microstructural analysis of glial fibrillary acidic protein (GFAP)- and glutamine synthetase (GS)-positive astrocytes performed in the entorhinal cortex (EC) of human SAD and FAD samples. In this study, we report prominent atrophic changes in GFAP and GS astrocytes in the EC of both SAD and FAD characterised by a decrease in area and volume when compared with non-demented control samples (ND). Furthermore, we did not find neither astrocytic loss nor astrocyte proliferation or hypertrophy (gliosis). In contrast with the astrogliosis classically accepted hypothesis, our results show a highly marked astrocyte atrophy that could have a major relevance in AD pathological processes being fundamental and key for AD mnesic and cognitive alterations equivalent in both SAD and FAD.
Identifiants
pubmed: 37730895
doi: 10.1007/s00429-023-02707-x
pii: 10.1007/s00429-023-02707-x
pmc: PMC10587264
doi:
Substances chimiques
Glial Fibrillary Acidic Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2103-2113Subventions
Organisme : Grantová Agentura České Republiky
ID : GACR 309/09/1696
Organisme : the Spanish Government Plan Nacional de I+D+I 2008-2011, and ISCIII Subdirección General de Evaluación y Fomento de la investigación co-financed by FEDER
ID : PI10/02738
Organisme : Government of the Basque Country
ID : AE-2010-1-28
Organisme : Spanish Ministerio de Economía y Competitividad, RETOS Colaboración co-financed by FEDER and by the Ministry of Italian University and Research
ID : RTC-2015-3542-1
Informations de copyright
© 2023. The Author(s).
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