Transcriptional linkage analysis with in vivo AAV-Perturb-seq.
Animals
Humans
Mice
Dependovirus
/ genetics
Gene Editing
Genetic Association Studies
/ methods
Neurons
/ metabolism
Phenotype
Prefrontal Cortex
/ metabolism
Transcription, Genetic
/ genetics
Single-Cell Analysis
/ methods
CRISPR-Cas Systems
/ genetics
DiGeorge Syndrome
/ drug therapy
Disease Models, Animal
RNA Processing, Post-Transcriptional
Synapses
/ pathology
Genetic Predisposition to Disease
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
22
09
2022
accepted:
25
08
2023
medline:
23
10
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype-phenotype relationships in complex tissues in a high-throughput manner
Identifiants
pubmed: 37730998
doi: 10.1038/s41586-023-06570-y
pii: 10.1038/s41586-023-06570-y
pmc: PMC10567566
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
367-375Informations de copyright
© 2023. The Author(s).
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