Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease.

Animals Chlorocebus aethiops Nipah Virus Ebola Vaccines Henipavirus Infections / prevention & control Vesicular Stomatitis Hemorrhagic Fever, Ebola Antibodies, Neutralizing
Nipah virus immune correlate neutralizing antibody recombinant VSV vaccine

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 03 05 2023
accepted: 16 08 2023
medline: 22 9 2023
pubmed: 21 9 2023
entrez: 21 9 2023
Statut: epublish

Résumé

Immune correlates of protection afforded by PHV02, a recombinant vesicular stomatitis (rVSV) vector vaccine against Nipah virus (NiV) disease, were investigated in the African green monkey (AGM) model. Neutralizing antibody to NiV has been proposed as the principal mediator of protection against future NiV infection. Two approaches were used to determine the correlation between neutralizing antibody levels and outcomes following a severe (1,000 median lethal doses) intranasal/intratracheal (IN/IT) challenge with NiV (Bangladesh): (1) reduction in vaccine dose given 28 days before challenge and (2) challenge during the early phase of the antibody response to the vaccine. Reduction in vaccine dose to very low levels led to primary vaccine failure rather than a sub-protective level of antibody. All AGMs vaccinated with the nominal clinical dose (2 × 10 It was concluded that PHV02 vaccine elicited a rapid onset of protection and that any detectable level of neutralizing antibody was a functional immune correlate of survival.

Identifiants

DOI: 10.3389/fimmu.2023.1216225 PMID: 37731485 PMC: PMC10507387
pubmed: 37731485
doi: 10.3389/fimmu.2023.1216225
pmc: PMC10507387
doi:

Substances chimiques

Ebola Vaccines 0
Antibodies, Neutralizing 0

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1216225

Informations de copyright

Copyright © 2023 Monath, Nichols, Feldmann, Griffin, Haddock, Callison, Meade-White, Okumura, Lovaglio, Hanley, Clancy, Shaia, Rida and Fusco.

Déclaration de conflit d'intérêts

TM is employed by Crozet Biopharma LLC. RN and JF are employed by Public Health Vaccines Inc. WR is an independent consultant. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Lancet. 2017 Feb 4;389(10068):505-518
pubmed: 28017403
Vaccine. 2015 Jun 4;33(24):2823-9
pubmed: 25865472
Semin Immunol. 2020 Aug;50:101413
pubmed: 33127296
Comp Med. 2010 Oct;60(5):389-95
pubmed: 21262125
Nat Med. 2021 Jul;27(7):1205-1211
pubmed: 34002089
NPJ Vaccines. 2016;1:
pubmed: 28706736
Nat Struct Mol Biol. 2021 May;28(5):426-434
pubmed: 33927387
J Infect Dis. 2016 Oct 15;214(suppl 3):S360-S366
pubmed: 27496978
Front Immunol. 2021 Oct 27;12:774026
pubmed: 34777392
J Infect Dis. 2020 May 11;221(Suppl 4):S436-S447
pubmed: 32022850
Ann Neurol. 2002 Jun;51(6):703-8
pubmed: 12112075
Indian J Community Med. 2019 Oct-Dec;44(4):383-387
pubmed: 31802805
PLoS Pathog. 2009 Oct;5(10):e1000642
pubmed: 19888339
Cell Rep. 2021 Aug 31;36(9):109628
pubmed: 34469726
Can J Neurol Sci. 2002 Feb;29(1):83-7
pubmed: 11858542
Arch Virol. 2012 Sep;157(9):1635-41
pubmed: 22669317
Microorganisms. 2022 Jun 06;10(6):
pubmed: 35744680
Sci Transl Med. 2017 Apr 12;9(385):
pubmed: 28404856
Malays J Pathol. 2007 Dec;29(2):63-7
pubmed: 19108397
Sci Rep. 2016 Aug 03;6:30916
pubmed: 27484128
NPJ Vaccines. 2020 Dec 17;5(1):112
pubmed: 33335092
Epidemiol Infect. 2019 Jan;147:e95
pubmed: 30869046
J Pathol. 2015 Jan;235(2):196-205
pubmed: 25229234
Vaccine. 2014 May 7;32(22):2637-44
pubmed: 24631094
J Virol. 2011 Aug;85(15):7658-71
pubmed: 21593160
Cell. 2020 Dec 10;183(6):1536-1550.e17
pubmed: 33306954
Clin Infect Dis. 2008 Apr 1;46(7):977-84
pubmed: 18444812
Lancet Infect Dis. 2017 Aug;17(8):854-866
pubmed: 28606591
JCI Insight. 2019 Jul 25;4(14):
pubmed: 31341108
PLoS Negl Trop Dis. 2017 Apr 7;11(4):e0005532
pubmed: 28388650
Emerg Microbes Infect. 2019;8(1):272-281
pubmed: 30866781
PLoS Pathog. 2022 Jun 27;18(6):e1010658
pubmed: 35759511
Emerg Infect Dis. 2007 Jul;13(7):1031-7
pubmed: 18214175

Auteurs

Thomas P Monath (TP)

Crozet Biopharma LLC, Lexington, MA, United States.
Public Health Vaccines Inc., Cambridge, MA, United States.

Richard Nichols (R)

Public Health Vaccines Inc., Cambridge, MA, United States.

Friederike Feldmann (F)

Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Amanda Griffin (A)

Laboratory of Virology, Division of Intramural Studies, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Elaine Haddock (E)

Laboratory of Virology, Division of Intramural Studies, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Julie Callison (J)

Laboratory of Virology, Division of Intramural Studies, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Kimberly Meade-White (K)

Laboratory of Virology, Division of Intramural Studies, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Atsushi Okumura (A)

Laboratory of Virology, Division of Intramural Studies, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Jamie Lovaglio (J)

Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Patrick W Hanley (PW)

Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Chad S Clancy (CS)

Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Carl Shaia (C)

Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States.

Wasima Rida (W)

Biostatistics Consultant, Arlington, VA, United States.

Joan Fusco (J)

Public Health Vaccines Inc., Cambridge, MA, United States.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Immunological correlates of protection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Immunological correlates of protection...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Henipavirus › Virus Nipah › Immunological correlates of protection...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la maladie à virus Ebola › Immunological correlates of protection...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Mononegavirales › Infections à Paramyxoviridae › Infections à hénipavirus › Immunological correlates of protection...
questionsmedicales.fr › Maladies de l'animal › Stomatite vésiculeuse › Immunological correlates of protection...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Mononegavirales › Infections à Filoviridae › Fièvre hémorragique à virus Ebola › Immunological correlates of protection...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Immunological correlates of protection...