Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol.

Developmental neuroscience Genomics In vitro toxicology Neurotoxicology Stem cells research Transcriptomics

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
20 Oct 2023
Historique:
received: 27 03 2023
revised: 30 06 2023
accepted: 24 08 2023
medline: 21 9 2023
pubmed: 21 9 2023
entrez: 21 9 2023
Statut: epublish

Résumé

Prenatal paracetamol exposure has been associated with neurodevelopmental outcomes in childhood. Pharmacoepigenetic studies show differences in cord blood DNA methylation between unexposed and paracetamol-exposed neonates, however, causality and impact of long-term prenatal paracetamol exposure on brain development remain unclear. Using a multi-omics approach, we investigated the effects of paracetamol on an

Identifiants

pubmed: 37731623
doi: 10.1016/j.isci.2023.107755
pii: S2589-0042(23)01832-1
pmc: PMC10507163
doi:

Types de publication

Journal Article

Langues

eng

Pagination

107755

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Mari Spildrejorde (M)

PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Athina Samara (A)

Division of Clinical Paediatrics, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.

Ankush Sharma (A)

Department of Informatics, University of Oslo, Oslo, Norway.
Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Biosciences, University of Oslo, Oslo, Norway.

Magnus Leithaug (M)

PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Martin Falck (M)

PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Department of Biosciences, University of Oslo, Oslo, Norway.

Stefania Modafferi (S)

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Arvind Y M Sundaram (AYM)

Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Ganesh Acharya (G)

Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Alfred Nobels Allé 8, SE-14152 Stockholm, Sweden.
Center for Fetal Medicine, Karolinska University Hospital, SE-14186 Stockholm, Sweden.

Hedvig Nordeng (H)

PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, University of Oslo, Oslo, Norway.

Ragnhild Eskeland (R)

PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.

Kristina Gervin (K)

PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Pharmacoepidemiology and Drug Safety Research Group, Department of Pharmacy, University of Oslo, Oslo, Norway.
Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.

Robert Lyle (R)

PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Classifications MeSH