Synthesis, biological evaluation and computer-aided discovery of new thiazolidine-2,4-dione derivatives as potential antitumor VEGFR-2 inhibitors.


Journal

RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657

Informations de publication

Date de publication:
18 Sep 2023
Historique:
received: 21 08 2023
accepted: 11 09 2023
medline: 21 9 2023
pubmed: 21 9 2023
entrez: 21 9 2023
Statut: epublish

Résumé

In this study, novel VEGFR-2-targeting thiazolidine-2,4-dione derivatives with potential anticancer properties were designed and synthesized. The ability of the designed derivatives to inhibit VEGFR-2 and stop the growth of three different cancer cell types (HT-29, A-549, and HCT-116) was examined

Identifiants

pubmed: 37731835
doi: 10.1039/d3ra05689a
pii: d3ra05689a
pmc: PMC10508263
doi:

Types de publication

Journal Article

Langues

eng

Pagination

27801-27827

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

There are no conflicts of interest to declare.

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Auteurs

Hazem Elkady (H)

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt Hazemelkady@azhar.edu.eg alaaelwan34@azhar.edu.eg mohammad1533.el@azhar.edu.eg hazem_hady2001@azhar.edu.eg mohammeddahab@azhar.edu.eg Ibrahimeissa@azhar.edu.eg.

Osama A El-Dardir (OA)

Undergraduate Student, Faculty of Pharmacy, Al-Azhar University Cairo 11884 Egypt Osamaeldardiri.2.stu.1@azhar.edu.eg.

Alaa Elwan (A)

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt Hazemelkady@azhar.edu.eg alaaelwan34@azhar.edu.eg mohammad1533.el@azhar.edu.eg hazem_hady2001@azhar.edu.eg mohammeddahab@azhar.edu.eg Ibrahimeissa@azhar.edu.eg.

Mohammed S Taghour (MS)

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt Hazemelkady@azhar.edu.eg alaaelwan34@azhar.edu.eg mohammad1533.el@azhar.edu.eg hazem_hady2001@azhar.edu.eg mohammeddahab@azhar.edu.eg Ibrahimeissa@azhar.edu.eg.

Hazem A Mahdy (HA)

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt Hazemelkady@azhar.edu.eg alaaelwan34@azhar.edu.eg mohammad1533.el@azhar.edu.eg hazem_hady2001@azhar.edu.eg mohammeddahab@azhar.edu.eg Ibrahimeissa@azhar.edu.eg.

Mohammed A Dahab (MA)

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt Hazemelkady@azhar.edu.eg alaaelwan34@azhar.edu.eg mohammad1533.el@azhar.edu.eg hazem_hady2001@azhar.edu.eg mohammeddahab@azhar.edu.eg Ibrahimeissa@azhar.edu.eg.

Eslam B Elkaeed (EB)

Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University Riyadh 13713 Saudi Arabia ikaeed@mcst.edu.sa.

Bshra A Alsfouk (BA)

Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia baalsfouk@pnu.edu.sa.

Ibrahim M Ibrahim (IM)

Biophysics Department, Faculty of Science, Cairo University Giza 12613 Egypt ibrahim_mohamed@cu.edu.eg.

Dalal Z Husein (DZ)

Chemistry Department, Faculty of Science, New Valley University El-Kharja 72511 Egypt dalal_husein@sci.nvu.edu.eg.

Elsayed E Hafez (EE)

Plant Protection and Biomolecular Diagnosis, ALCRI, City of scientific research and technological applications New Borg El-Arab City Alexandria 21934 Egypt elsayed_hafez@yahoo.com.

Amira M G Darwish (AMG)

Food Industry Technology Program, Faculty of Industrial and Energy Technology, Borg Al Arab Technological University Alexandria Egypt.
Food Technology Department, Arid Lands Cultivation Research Institute, City of Scientific Research and Technological Applications (SRTA-City) Alexandria 21934 Egypt amiragdarwish@yahoo.com.

Ahmed M Metwaly (AM)

Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt.

Ibrahim H Eissa (IH)

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University Cairo 11884 Egypt Hazemelkady@azhar.edu.eg alaaelwan34@azhar.edu.eg mohammad1533.el@azhar.edu.eg hazem_hady2001@azhar.edu.eg mohammeddahab@azhar.edu.eg Ibrahimeissa@azhar.edu.eg.

Classifications MeSH