Optimization and evaluation of oxygen-plasma-modified, aligned, poly (Є-caprolactone) and silk fibroin nanofibrous scaffold for corneal stromal regeneration.
Nanofibre
Oxygen-plasma surface modification
Silk fibroin
Stromal regeneration
Journal
Biomaterials and biosystems
ISSN: 2666-5344
Titre abrégé: Biomater Biosyst
Pays: England
ID NLM: 9918250307706676
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
02
06
2023
revised:
28
08
2023
accepted:
02
09
2023
medline:
21
9
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
epublish
Résumé
The shortage of human donor corneas for transplantation necessitates the exploration of tissue engineering approaches to develop corneal substitutes. However, these substitutes must possess the necessary strength, transparency, and ability to regulate cell behaviour before they can be used in patients. In this study, we investigated the effectiveness of an oxygen plasma surface-modified poly-ε-caprolactone (PCL) combined with silk fibroin (SF) nanofibrous scaffold for corneal stromal regeneration. To fabricate the electrospun scaffolds, PCL and SF blends were used on a rotating mandrel. The optimization of the blend aimed to replicate the structural and functional properties of the human cornea, focusing on nanofibre alignment, mechanical characteristics, and
Identifiants
pubmed: 37731910
doi: 10.1016/j.bbiosy.2023.100083
pii: S2666-5344(23)00012-0
pmc: PMC10507194
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100083Informations de copyright
© 2023 The Authors. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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