Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma.
WEE1
docetaxel
esophageal adenocarcinoma
miRNA
patient-derived xenograft
smoking
Journal
Molecular therapy oncolytics
ISSN: 2372-7705
Titre abrégé: Mol Ther Oncolytics
Pays: United States
ID NLM: 101666776
Informations de publication
Date de publication:
21 Sep 2023
21 Sep 2023
Historique:
received:
21
07
2023
accepted:
24
08
2023
medline:
21
9
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
epublish
Résumé
Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for EAC. The role of WEE1, a nuclear kinase that negatively regulates the cell cycle in normal conditions, in EAC tumorigenesis and drug resistance is not fully understood. Immunohistochemistry staining shows significant WEE1 overexpression in human EAC tissues. Nicotine, nicotine-derived nitrosamine ketone, or 2% cigarette smoke extract treatment induces WEE1 protein expression in EAC, detected by western blot and immunofluorescence staining. qRT-PCR and reporter assay indicates that smoking induces WEE1 expression through miR-195-5p downregulation in EAC. ATP-Glo cell viability and clonogenic assay confirmed that WEE1 inhibition sensitizes EAC cells to docetaxel treatment
Identifiants
pubmed: 37732296
doi: 10.1016/j.omto.2023.08.012
pii: S2372-7705(23)00066-9
pmc: PMC10507159
doi:
Types de publication
Journal Article
Langues
eng
Pagination
286-300Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Pancreas. 2022 Feb 1;51(2):190-195
pubmed: 35404896
Front Immunol. 2021 Dec 09;12:743938
pubmed: 34956177
Clin Cancer Res. 2017 Oct 15;23(20):6239-6253
pubmed: 28698200
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
EBioMedicine. 2016 Oct;12:34-42
pubmed: 27720213
J Clin Oncol. 2015 Oct 20;33(30):3485-7
pubmed: 26215953
Oncogene. 2013 Jan 10;32(2):151-9
pubmed: 22330135
Bioinformatics. 2018 Jun 15;34(12):2150-2152
pubmed: 29420694
PLoS One. 2022 Sep 1;17(9):e0271950
pubmed: 36048826
J Med Internet Res. 2021 Jul 26;23(7):e27633
pubmed: 34309564
Gastric Cancer. 2021 Sep;24(5):1003-1020
pubmed: 33723720
Cancer. 2013 Mar 15;119(6):1149-58
pubmed: 23303625
Med Sci Monit. 2016 Jun 02;22:1872-9
pubmed: 27253431
Dis Markers. 2017;2017:8317913
pubmed: 28487599
Mol Oncol. 2021 Apr;15(4):1130-1145
pubmed: 33320980
DNA Repair (Amst). 2021 Nov;107:103203
pubmed: 34390915
Gastroenterology. 2012 Feb;142(2):233-40
pubmed: 22062359
J Thorac Dis. 2014 Jun;6(6):649-55
pubmed: 24976986
J Chemother. 2013 Aug;25(4):229-38
pubmed: 23816136
Gastroenterology. 2022 Sep;163(3):649-658.e2
pubmed: 35671803
PLoS One. 2013 May 28;8(5):e64463
pubmed: 23724052
Mol Cancer Ther. 2013 Dec;12(12):2675-84
pubmed: 24121103
Molecules. 2017 Nov 23;22(12):
pubmed: 29168755
Pharmacol Res. 2020 Oct;160:105087
pubmed: 32683036
Int J Mol Sci. 2021 Mar 05;22(5):
pubmed: 33807717
Int J Biomed Sci. 2017 Mar;13(1):20-25
pubmed: 28533733
PLoS One. 2012;7(5):e36503
pubmed: 22567160
Biomed Pharmacother. 2022 Jun;150:112885
pubmed: 35453003
Cancer. 2013 Feb 15;119(4):904-14
pubmed: 22972611
Mol Oncol. 2022 Aug;16(15):2881-2895
pubmed: 35593085
Int J Cancer. 2015 May 15;136(10):2253-63
pubmed: 25346222
Reprod Sci. 2017 Jul;24(7):989-995
pubmed: 28285568
Cancer Res. 2002 Dec 1;62(23):6823-6
pubmed: 12460893
Gastroenterology. 2013 Dec;145(6):1312-22.e1-8
pubmed: 23993973
Oncogene. 2022 Jan;41(5):692-703
pubmed: 34819634
Digestion. 2009;80(4):209-14
pubmed: 19776585
PLoS One. 2018 Aug 27;13(8):e0201267
pubmed: 30148841
Int J Clin Exp Pathol. 2019 Jan 01;12(1):275-281
pubmed: 31933743
Cancer. 2013 Jun 1;119(11):1985-93
pubmed: 23456798
Cancer Cell. 2019 Jun 10;35(6):851-867.e7
pubmed: 31185210
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
PLoS One. 2022 Jul 27;17(7):e0268480
pubmed: 35895593
Gastroenterology. 2019 Mar;156(4):1127-1139.e8
pubmed: 30502323
Cells. 2022 Sep 07;11(18):
pubmed: 36139366
J Natl Compr Canc Netw. 2019 Jul 1;17(7):855-883
pubmed: 31319389
J Natl Cancer Inst. 2010 Sep 8;102(17):1344-53
pubmed: 20716718
Cancer Res. 2019 Nov 15;79(22):5884-5896
pubmed: 31585941
Mol Ther Nucleic Acids. 2022 Aug 24;29:803-822
pubmed: 36159587
BMC Genom Data. 2022 Nov 16;23(1):80
pubmed: 36384476
J Control Release. 2012 Dec 10;164(2):192-204
pubmed: 22613880
Gastroenterology. 2011 Nov;141(5):1738-48.e1-2
pubmed: 21741919
R Soc Open Sci. 2018 Nov 28;5(11):181321
pubmed: 30564416
RNA. 2008 May;14(5):844-52
pubmed: 18375788
Wien Med Wochenschr. 2015 Oct;165(19-20):379-86
pubmed: 26289596
Front Oncol. 2021 Sep 09;11:738477
pubmed: 34568075
Cancer Biol Ther. 2021 Sep 2;22(7-9):465-477
pubmed: 34486497
Oncol Rep. 1997 Sep-Oct;4(5):953-6
pubmed: 21590174
Clinics (Sao Paulo). 2013 Jun;68(6):825-33
pubmed: 23778472
Clin Cancer Res. 2014 Aug 15;20(16):4274-88
pubmed: 25125259