Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats.
Ayurveda
Indian traditional medicine
antitubercular treatment
drug induced liver injury
liver injury
phytochemical
scopoletin
Journal
Journal of complementary & integrative medicine
ISSN: 1553-3840
Titre abrégé: J Complement Integr Med
Pays: Germany
ID NLM: 101313855
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
13
06
2023
accepted:
28
08
2023
pubmed:
21
9
2023
medline:
21
9
2023
entrez:
21
9
2023
Statut:
epublish
Résumé
The hepatoprotective properties of scopoletin have been explored in carbon tetrachloride (CCl4) induced liver injury but not in drug-induced liver injury (DILI) scenarios. Only N-acetyl-cysteine (NAC) has proven efficacy in DILI treatment. Accordingly, we conducted a study to assess the hepatoprotective action of scopoletin in the anti-tubercular treatment (ATT)-DILI model in Wistar rats, if any. A total of 36 rats were evaluated, with six in each group. A 36-day ATT at 100 mg/kg dose for isoniazid, 300 mg/kg for rifampicin and 700 mg/kg for pyrazinamide were fed to induce hepatotoxicity in rats. Group I and II-VI received normal saline and ATT, respectively. Oral scopoletin (1,5 and 10 mg/kg) and NAC 150 mg/kg were administered in groups III, IV, V and VI, respectively, once daily for the last 15 days of the experiment. LFT monitoring was performed at baseline, days 21, 28, and 36. Rats were sacrificed for the histopathology examination. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and bilirubin levels were significantly increased in group II (receiving ATT) compared to normal control on day 28 and day 36 (p<0.05). All three doses of scopoletin and NAC groups led to the resolution of AST, ALT, ALP, and bilirubin changes induced by ATT medications effect beginning by day 28 and persisting on day 36 (p<0.01). An insignificant effect was observed on albumin and total protein levels. The effect was confirmed with antioxidants and histopathology analysis. The study confirms the hepatoprotective efficacy of scopoletin in a more robust commonly encountered liver injury etiology.
Identifiants
pubmed: 37732506
pii: jcim-2023-0168
doi: 10.1515/jcim-2023-0168
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-803Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
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